Flat-Coated Retriever — Histiocytosis, malignant (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_flat_coated_retriever_omia1188_dog category: companion-breed-health title: "Flat-Coated Retriever — Histiocytosis, malignant (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/flat_coated_retriever_omia1188_1188.txt date_parsed: 2026-08-02 tokens_estimated: 189 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_flat_coated_retriever_omia1188_dog/01_companion_breed_health_flat_coated_retriever_omia1188_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Flat-Coated Retriever — Histiocytosis, malignant (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000620/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Flat-Coated Retriever — Histiocytosis, malignant (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: Flat-Coated Retriever (Dog)
• Disorder:
• Mode of inheritance: Multifactorial
• Defect: yes
• Gen test: A pre-test, based on the results of Shearin et al. (2012) is available from Antagene: http://www.antagene.com/en/commander/histiocytic-sarcoma-pre-test. Given the results reported by Asada et al. (2019), namely that The mutation was detected in [only] 26 of 64 [affected] dogs (41%) and their conclusion that HS cells might acquire insAT in the TP53 gene during development of metastasis, but insAT was not a prognostic factor in canine HS, it would seem that insAT is not a useful marker. It has, therefore, been removed from the OMIA table of likely causal variants.

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: P53 (Entrez Gene ID 403869) — OMIA Phene_Gene / GeneSynonym

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 1993. Disseminated malignant histiocytosis in a Golden Retriever - clinicopathologic, ultrastructural, and immunohistochemical findings. Vet Pathol — PubMed:PMID8333107 | DOI:10.1177/030098589303000306 — OMIA Phene_Article / Article
• 1995. Inheritance of histiocytosis in Bernese mountain dogs. Journal of Small Animal Practice — PubMed:PMID7783441 — OMIA Phene_Article / Article
• 1995. Systemic histiocytosis in the Bernese mountain dog. Journal of Small Animal Practice — PubMed:PMID7650919 — OMIA Phene_Article / Article
• 1996. Malignant histiocytosis in three Bernese Mountain dogs. Veterinary Record — PubMed:PMID8735262 — OMIA Phene_Article / Article
• 2009. Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed. J Hered — PubMed:PMID19531730 | DOI:10.1093/jhered/esp039 — OMIA Phene_Article / Article
• 2010. Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark. Vet Rec — PubMed:PMID20154310 | DOI:10.1136/vr.b4756 — OMIA Phene_Article / Article
• 2011. Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer — PubMed:PMID21615919 | DOI:10.1186/1471-2407-11-201 — OMIA Phene_Article / Article
• 2006. Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs. Am J Vet Res — PubMed:PMID16579756 | DOI:10.2460/ajvr.67.4.633 — OMIA Phene_Article / Article
• 2012. The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. Cancer Epidemiol Biomarkers Prev — PubMed:PMID22623710 | DOI:10.1158/1055-9965.EPI-12-0190-T — OMIA Phene_Article / Article
• 2013. Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci — PubMed:PMID23738139 | DOI:10.1155/2013/941275 — OMIA Phene_Article / Article
• 2013. Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog. PLoS One — PubMed:PMID23936488 | DOI:10.1371/journal.pone.0071094 — OMIA Phene_Article / Article
• 2015. Histiocytic sarcoma with central nervous system involvement in dogs: 19 cases (2006-2012). J Vet Intern Med — PubMed:PMID25711602 | DOI:10.1111/jvim.12554 — OMIA Phene_Article / Article
• (69 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:191170 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."