--- license: permission_granted topic_id: companion_breed_health_dogo_argentino_omia4767_dog category: companion-breed-health title: "Dogo Argentino — Dwarfism, PRKG2-related (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/dogo_argentino_omia4767_4767.txt date_parsed: 2026-08-02 tokens_estimated: 248 verification: method: substring_match claims: 6 passed: 6 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_dogo_argentino_omia4767_dog/01_companion_breed_health_dogo_argentino_omia4767_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dogo Argentino — Dwarfism, PRKG2-related (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001485/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Dogo Argentino — Dwarfism, PRKG2-related (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Dogo Argentino (Dog)Disorder:Mode of inheritance: Autosomal recessiveClin feat: Rudd Garces et al. (2021) investigated a family of nine Dogo Argentino dogs, in which two dogs were affected by disproportionate dwarfism. Radiographs of an affected dog revealed a decreased level of endochondral ossification in its growth plates, and a premature closure of the distal ulnar physes.brMäkeläinen et al. (2025): affected [Dalmation] dogs had short legs and showed clear gait abnormalities. The front legs were curved with an outward-angled elbow joint and an outward rotation of the paw. Due to the severity of the condition, the affected dogs were euthanized ....Defect: yesPathology: Mäkeläinen et al. (2025): Microscopically, the growth plates of the distal ulna and radius [of affected Dalmation dogs] were irregular showing disorganized areas of resting, proliferative and hypertrophic zones ... .
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 388253078 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Rudd Garces et al. (2021): "The genome of an affected dog was sequenced and compared to 795 control genomes. The prioritization of private variants revealed a clear top candidate variant for the observed dwarfism. This variant, PRKG2:XM_022413533.1:c.1634+1G>T [omia.variant:1373], affects the splice donor site and is therefore predicted to disrupt the function of the PKRG2 gene .... "<br>Mäkelä…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2021. PRKG2 splice site variant in Dogo Argentino dogs with disproportionate dwarfism. Genes (Basel) — PubMed:PMID34680883 | DOI:10.3390/genes12101489 — OMIA Phene_Article / Article
- 2025. A nonsense mutation in the PRKG2 gene in dalmatian dogs with chondrodysplasia. PLoS One — PubMed:PMID41296694 | DOI:10.1371/journal.pone.0322107 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:601591 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."