--- license: permission_granted topic_id: companion_breed_health_doberman_pinscher_dings_dog category: companion-breed-health title: "Doberman Pinscher — DINGS (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/doberman_pinscher_dings_4109.txt date_parsed: 2026-08-02 tokens_estimated: 162 verification: method: substring_match claims: 6 passed: 6 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_doberman_pinscher_dings_dog/01_companion_breed_health_doberman_pinscher_dings_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Doberman Pinscher — DINGS (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA002148/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Doberman Pinscher — DINGS (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Doberman Pinscher (Dog)Disorder: DINGSMode of inheritance: Autosomal recessiveSummary: See also: a href=https://omia.org/OMIA002196/9615/OMIA:002196-9615/a : Deafness, unilateral and vestibular dysfunction, PTPRQ-relatednbsp; in Canis lupus familiaris (dog)Defect: yesPrevalence: Webb et al. (2019): Of 632 [unaffected Doberman Pinscher] dogs tested, none were homozygous. We found that 62 dogs were heterozygous for the mutation, suggesting an allele frequency of 4.9% (62/1224 chromosomes sampled) and a carrier frequency in the breed of nearly 10%.
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 388251254 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Analysis of sequence in the mapped region of an affected Doberman Pinscher enabled Webb et al. (2019) to identify a missence mutation in the MYO7A gene (c.3719G>A; p.R1240Q) as the likely causal variant. All affected dogs were homozygous for this variant.
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1992. Congenital deafness and vestibular deficit in the Dobermann. Journal of Small Animal Practice — DOI:10.1111/j.1748-5827.1992.tb01120.x — OMIA Phene_Article / Article
- 2005. Congenital sensorineural deafness in dogs: a molecular genetic approach toward unravelling the responsible genes. Vet J — PubMed:PMID15727910 | DOI:10.1016/j.tvjl.2004.01.015 — OMIA Phene_Article / Article
- 2012. Canine deafness. Vet Clin North Am Small Anim Pract — PubMed:PMID23122177 | DOI:10.1016/j.cvsm.2012.08.010 — OMIA Phene_Article / Article
- 2019. A missense mutation in MYO7A is associated with bilateral deafness and vestibular dysfunction in the Doberman pinscher breed. Can J Vet Res — PubMed:PMID31097876 — OMIA Phene_Article / Article
- 2023. An overview of canine inherited neurological disorders with known causal variants. Animals (Basel) — PubMed:PMID38003185 | DOI:10.3390/ani13223568 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:276900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:600060 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:601317 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:276903 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."