Dandie Dinmont Terrier — Glaucoma, primary closed-angle (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_dandie_dinmont_terrier_omia3629_dog category: companion-breed-health title: "Dandie Dinmont Terrier — Glaucoma, primary closed-angle (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/dandie_dinmont_terrier_omia3629_3629.txt date_parsed: 2026-08-02 tokens_estimated: 139 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_dandie_dinmont_terrier_omia3629_dog/01_companion_breed_health_dandie_dinmont_terrier_omia3629_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dandie Dinmont Terrier — Glaucoma, primary closed-angle (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001871/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Dandie Dinmont Terrier — Glaucoma, primary closed-angle (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: Dandie Dinmont Terrier (Dog)
• Disorder:
• Mode of inheritance: Autosomal recessive
• Summary: This disorder in Dandie Dinmont Terriers was first described by Ahonen et al. (2013). Several studies investigated the condition in Basset Hounds (Ahram et al.,2014, 2015; Oliver et al., 2019). Park et al. (2022) reported that the American Cocker Spaniel (ACS) is among the most common breeds observed with PACG [primary angle closure glaucoma] development in dogs.
• Defect: yes

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: Entrez Gene ID 388244698 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
• OMIA molecular-genetics note: Ahram et al. (2015) reported a potentially pathogenic missense mutation in the nebulin gene (NEB) (g.5588214 A->G in exon 48; p.2051 Lys->Arg), which is located in their candidate region of CFA19q, as being strongly (but not completely) associated with the disorder in Basset Hounds.

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2013. Genome-wide association study identifies a novel canine glaucoma locus. PLoS One — PubMed:PMID23951034 | DOI:10.1371/journal.pone.0070903 — OMIA Phene_Article / Article
• 2015. Progression of pectinate ligament dysplasia over time in two populations of Flat-Coated Retrievers. Vet Ophthalmol — PubMed:PMID24025050 | DOI:10.1111/vop.12098 — OMIA Phene_Article / Article
• 2015. Variants in nebulin (NEB) are linked to the development of familial primary angle closure glaucoma in Basset Hounds. PLoS One — PubMed:PMID25938837 | DOI:10.1371/journal.pone.0126660 — OMIA Phene_Article / Article
• 2014. Identification of genetic loci associated with primary angle-closure glaucoma in the basset hound. Mol Vis — PubMed:PMID24791135 — OMIA Phene_Article / Article
• 2015. Genetics of canine primary glaucomas. Vet Clin North Am Small Anim Pract — PubMed:PMID26277300 | DOI:10.1016/j.cvsm.2015.06.003 — OMIA Phene_Article / Article
• 2015. Definition, classification, and pathophysiology of canine glaucoma. Vet Clin North Am Small Anim Pract — PubMed:PMID26456751 | DOI:10.1016/j.cvsm.2015.06.002 — OMIA Phene_Article / Article
• 2017. Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol — PubMed:PMID27681326 | DOI:10.1177/0300985816666611 — OMIA Phene_Article / Article
• 2019. Primary closed angle glaucoma in the Basset Hound: Genetic investigations using genome-wide association and RNA sequencing strategies. Mol Vis — PubMed:PMID30820145 — OMIA Phene_Article / Article
• 2021. Proteomic analysis of aqueous humor in canine primary angle-closure glaucoma in American Cocker Spaniel dogs. Vet Ophthalmol — PubMed:PMID34558166 | DOI:10.1111/vop.12937 — OMIA Phene_Article / Article
• 2021. Evaluation of matrix metalloproteinases and tissue inhibitors of metalloproteinases in aqueous humor of dogs with versus without naturally occurring primary angle-closure glaucoma. Am J Vet Res — PubMed:PMID34936570 | DOI:10.2460/ajvr.21.04.0062 — OMIA Phene_Article / Article
• 2022. Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility. Sci Rep — PubMed:PMID36348026 | DOI:10.1038/s41598-022-23238-1 — OMIA Phene_Article / Article
• 2015. Ocular Disorders Presumed to be Inherited in Purebred Dogs (“The Blue Book”), 8th edition — OMIA Phene_Article / Article
• (4 additional references in OMIA)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."