--- license: permission_granted topic_id: companion_breed_health_chinook_omia3653_dog category: companion-breed-health title: "Chinook — Chondrodysplasia, disproportionate short-limbed, ITGA10-related' (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/chinook_omia3653_3653.txt date_parsed: 2026-08-02 tokens_estimated: 311 verification: method: substring_match claims: 6 passed: 6 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_chinook_omia3653_dog/01_companion_breed_health_chinook_omia3653_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Chinook — Chondrodysplasia, disproportionate short-limbed, ITGA10-related' (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001886/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Chinook — Chondrodysplasia, disproportionate short-limbed, ITGA10-related' (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Chinook (Dog)Disorder:Mode of inheritance: Autosomal recessiveClin feat: As reported by Bingel and Sande (1982): Radiographic changes included flaring and increased width of the distal metaphyses of the radius and ulna, delayed ossification of the cuboid bones of the carpus, and reduction in length of the vertebral bodies. The zone of chondrocyte proliferation was decreased in width and contained areas of abnormal cell column formation alternated with wide areas of matrix. Chondrocytes in all zones contained one or more inclusions bounded by a smooth discontinuous membrane. The material within the inclusions appeared homogeneous and stained blue-green with Movat's pentachrome and deep blue with alcian blue-periodic acid-Schiff at pH 1.0 and 2.6. The distribution of ruthenium red granules in the matrix frequently revealed poor differentiation into territorial and interterritorial zones.Defect: yesPrevalence: As reported by Kyöstilä et al. (2013), Carrier frequency of the c.2083Cgt;T mutation was 24% in a cohort of 156 randomly selected Finnish NEs [Norwegian Elkhound] and 8% in a population sample of 287 KBDs [Karelian bear dog].
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 388303744 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: The most likely functional candidate gene in the region mapped by Kyöstilä et al. (2013) (see above) was <em>ITAG10</em>, encoding integrin subunit alpha 10. Sequencing all exons in this gene in two affecteds, an obligate carrier and a half-sib of an affected dog, revealed four exonic SNVs, namely three synonymous and one nonsense (c.2083C>T in exon 16; p.Arg695*) [omia.variant:336]. Widespread…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1982. Chondrodysplasia in the Norwegian Elkhound. Am J Pathol — PubMed:PMID7081383 — OMIA Phene_Article / Article
- 2013. Canine chondrodysplasia caused by a truncating mutation in collagen-binding integrin alpha subunit 10. PLoS One — PubMed:PMID24086591 | DOI:10.1371/journal.pone.0075621 — OMIA Phene_Article / Article
- 2016. Genetic panel screening of nearly 100 mutations reveals new insights into the breed distribution of risk variants for canine hereditary disorders. PLoS One — PubMed:PMID27525650 | DOI:10.1371/journal.pone.0161005 — OMIA Phene_Article / Article
- 2023. Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture. Genome Biol — PubMed:PMID37582787 | DOI:10.1186/s13059-023-03023-7 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:604042 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."