Chinese Shar-Pei — Entropion (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_chinese_shar_pei_omia604_dog category: companion-breed-health title: "Chinese Shar-Pei — Entropion (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/chinese_shar_pei_omia604_604.txt date_parsed: 2026-08-02 tokens_estimated: 130 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_chinese_shar_pei_omia604_dog/01_companion_breed_health_chinese_shar_pei_omia604_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Chinese Shar-Pei — Entropion (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000337/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Chinese Shar-Pei — Entropion (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

Breed: Chinese Shar-Pei (Dog)
Disorder:
Summary: Genetics Committee of the American College of Veterinary Opthalmologists (2021): Entropion is a conformational defect resulting in inversion of the eyelid margin which may cause ocular irritation. It is likely that entropion is influenced by several factors defining the skin and other structures, which make up the eyelids, orbital contents, and conformation of the skull.
Defect: yes

Causal variant(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

Variant: chromosome 19; nt change NM_001034039.2:c.4234G>A; protein NP_001029211.1:p.(D1412N); pathogenicity class 1 — OMIA Variant / Variant_Phene

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

1990. Bilateral congenital entropion in a female Karabas dog.. Praktische Tierarzt — OMIA Phene_Article / Article
1995. Ectropion and entropion in the Shar Pei [Dutch]. Vlaams Diergeneeskundig Tijdschrift — OMIA Phene_Article / Article
1999. Brow suspension for treatment of ptosis and entropion in dogs with redundant facial skin folds. Journal of the American Veterinary Medical Association — PubMed:PMID10088013 — OMIA Phene_Article / Article
2015. A retrospective survey of ocular abnormalities in pugs: 130 cases.. J Small Anim Pract — PubMed:PMID25370448 | DOI:10.1111/jsap.12291 — OMIA Phene_Article / Article
2016. Epidemiology of ocular disorders presumed to be inherited in three large Italian dog breeds in Italy.. Vet Ophthalmol — PubMed:PMID27860098 | DOI:10.1111/vop.12442 — OMIA Phene_Article / Article
2007. Entropion correction in dogs and cats using a combination Hotz-Celsus and lateral eyelid wedge resection: results in 311 eyes.. Vet Ophthalmol — PubMed:PMID17204122 | DOI:10.1111/j.1463-5224.2007.00482.x — OMIA Phene_Article / Article
2019. The use of hyaluronic acid subdermal filler for entropion in canines and felines: 40 cases.. Vet Ophthalmol — PubMed:PMID29520917 | DOI:10.1111/vop.12566 — OMIA Phene_Article / Article
2017. Epidemiology of ocular disorders presumed to be inherited in three small Italian dog breeds in Italy.. Vet Ophthalmol — PubMed:PMID29284193 | DOI:10.1111/vop.12542 — OMIA Phene_Article / Article
2023. Novel findings on the anatomy of medial canthus in dogs.. Vet Ophthalmol — PubMed:PMID36847328 | DOI:10.1111/vop.13072 — OMIA Phene_Article / Article
2023. A combination of modified Kuhnt-Szymanowski and Celsus-Hotz techniques for correction of entropion and overlong lower eyelids in dogs (40 eyes).. Vet Ophthalmol — PubMed:PMID36948518 | DOI:10.1111/vop.13084 — OMIA Phene_Article / Article
2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article
2024. Entropion - the most common condition in shar pei dogs.. Vet Rec — PubMed:PMID38180193 | DOI:10.1002/vetr.3803 — OMIA Phene_Article / Article
(6 additional references in OMIA)

Causal variant(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

Variant: chromosome 19; nt change NM_001034039.2:c.4234G>A; protein NP_001029211.1:p.(D1412N); pathogenicity class 1 — OMIA Variant / Variant_Phene