--- license: permission_granted topic_id: companion_breed_health_checkered_giant_omia2943_rabbit category: companion-breed-health title: "Checkered Giant — Coat colour, agouti (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump." source_file: pdf-raw/breed-health/checkered_giant_omia2943_2943.txt date_parsed: 2026-08-23 tokens_estimated: 178 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-23 recovered: false path: companion-breed-health/companion_breed_health_checkered_giant_omia2943_rabbit/01_companion_breed_health_checkered_giant_omia2943_rabbit.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Checkered Giant — Coat colour, agouti (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000201/9986/" retrieved: "2026-08-23" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Checkered Giant — Coat colour, agouti (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Checkered GiantDisorder:Mode of inheritance: AutosomalDefect: noPrevalence: Letko et al. (2020) genotyped 49 rabbits with different coat colours . . . . Out of 19 black and tan rabbits analysed, 17 carried the deletion in a homozygous state. The remaining two black and tan rabbits were heterozygous for the deletion but also heterozygous for the single base insertion, causing recessive black and thus presumably compound heterozygous a^t/a. As the a allele is recessive to a^t, rabbits with an a^t/a genotype are phenotypically black and tan. None of the 30 rabbits that were not black and tan carried the deletion in a homozygous state.
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 4215581 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2010. Characterization of the rabbit agouti signaling protein (ASIP) gene: transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour. Genomics — PubMed:PMID20004240 | DOI:10.1016/j.ygeno.2009.11.003 — OMIA Phene_Article / Article
- 1953. [Studies on the coat markings of wild rabbits; a contribution to the mechanism of the agouti factor.]. Z Indukt Abstamm Vererbungsl — PubMed:PMID13091004 — OMIA Phene_Article / Article
- 1958. Genetic studies of the rabbit. Bibliographia Genetica — OMIA Phene_Article / Article
- 2019. Multiple conserved elements structuring inverted repeats in the mammalian coat color-related gene Asip. Zoolog Sci — PubMed:PMID31116535 | DOI:10.2108/zs180081 — OMIA Phene_Article / Article
- 2020. A deletion spanning the promoter and first exon of the hair cycle-specific ASIP transcript isoform in black and tan rabbits. Anim Genet — PubMed:PMID31729778 | DOI:10.1111/age.12881 — OMIA Phene_Article / Article
- 2023. A genome-wide association study of coat color in Chinese Rex rabbits. Front Vet Sci — PubMed:PMID37655262 | DOI:10.3389/fvets.2023.1184764 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:611742 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:600201 (type: gene) — OMIA Group_OMIM (via OMIA_ID)