Cavalier King Charles Spaniel — Syringomyelia (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_cavalier_king_charles_spaniel_omia2243_dog category: companion-breed-health title: "Cavalier King Charles Spaniel — Syringomyelia (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/cavalier_king_charles_spaniel_omia2243_2243.txt date_parsed: 2026-08-02 tokens_estimated: 87 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_cavalier_king_charles_spaniel_omia2243_dog/01_companion_breed_health_cavalier_king_charles_spaniel_omia2243_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Cavalier King Charles Spaniel — Syringomyelia (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000965/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Cavalier King Charles Spaniel — Syringomyelia (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

Breed: Cavalier King Charles Spaniel (Dog)
Disorder:
Mode of inheritance: Multifactorial
Summary: See also a href=http://https//omia.org/OMIA001861/9615/OMIA:001861-9615/a : Chiari malformation Type I with syringomyelia in Canis lupus familiaris.brnbsp;
Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

1965. Spinal dysraphism in the dog, with comments on syringomylia. Pathologia Veterinaria — PubMed:PMID5893238 — OMIA Phene_Article / Article
1996. Syringomyelia and hydrocephalus in a dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article
2000. Syringohydromyelia in Cavalier King Charles spaniels. Journal of the American Animal Hospital Association — PubMed:PMID10667404 — OMIA Phene_Article / Article
2000. Syringomyelia and hydromyelia in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article
2000. Magnetic resonance imaging of syringomyelia in five dogs. Journal of Small Animal Practice — PubMed:PMID11002940 — OMIA Phene_Article / Article
2008. Syringomyelia in cavalier King Charles spaniels.. Vet Rec — PubMed:PMID18326849 — OMIA Phene_Article / Article
2008. Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting.. Aust Vet J — PubMed:PMID18271823 | DOI:10.1111/j.1751-0813.2007.00247.x — OMIA Phene_Article / Article
2008. Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia.. Am J Vet Res — PubMed:PMID18167092 | DOI:10.2460/ajvr.69.1.89 — OMIA Phene_Article / Article
2007. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain.. J Small Anim Pract — PubMed:PMID17608656 | DOI:10.1111/j.1748-5827.2007.00344.x — OMIA Phene_Article / Article
2008. Pathophysiology and treatment of neuropathic pain associated with syringomyelia.. Vet J — PubMed:PMID17317245 | DOI:10.1016/j.tvjl.2006.12.007 — OMIA Phene_Article / Article
2006. Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog.. J Vet Med Sci — PubMed:PMID17146188 — OMIA Phene_Article / Article
2006. Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel.. J Small Anim Pract — PubMed:PMID17004953 | DOI:10.1111/j.1748-5827.2006.00048.x — OMIA Phene_Article / Article
(46 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

OMIM:186700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

1965. Spinal dysraphism in the dog, with comments on syringomylia. Pathologia Veterinaria — PubMed:PMID5893238 — OMIA Phene_Article / Article
1996. Syringomyelia and hydrocephalus in a dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article
2000. Syringohydromyelia in Cavalier King Charles spaniels. Journal of the American Animal Hospital Association — PubMed:PMID10667404 — OMIA Phene_Article / Article
2000. Syringomyelia and hydromyelia in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article
2000. Magnetic resonance imaging of syringomyelia in five dogs. Journal of Small Animal Practice — PubMed:PMID11002940 — OMIA Phene_Article / Article
2008. Syringomyelia in cavalier King Charles spaniels. Vet Rec — PubMed:PMID18326849 — OMIA Phene_Article / Article
2008. Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting. Aust Vet J — PubMed:PMID18271823 | DOI:10.1111/j.1751-0813.2007.00247.x — OMIA Phene_Article / Article
2008. Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Am J Vet Res — PubMed:PMID18167092 | DOI:10.2460/ajvr.69.1.89 — OMIA Phene_Article / Article
2007. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract — PubMed:PMID17608656 | DOI:10.1111/j.1748-5827.2007.00344.x — OMIA Phene_Article / Article
2008. Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J — PubMed:PMID17317245 | DOI:10.1016/j.tvjl.2006.12.007 — OMIA Phene_Article / Article
2006. Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. J Vet Med Sci — PubMed:PMID17146188 — OMIA Phene_Article / Article
2006. Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract — PubMed:PMID17004953 | DOI:10.1111/j.1748-5827.2006.00048.x — OMIA Phene_Article / Article
(46 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

OMIM:186700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)