--- license: permission_granted topic_id: companion_breed_health_boxer_arrhythmogenic_right_ventricular_cardiomyopathy_dog category: companion-breed-health title: "Boxer — Arrhythmogenic right ventricular cardiomyopathy (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/boxer_arrhythmogenic_right_ventricular_cardiomyopathy_1564.txt date_parsed: 2026-08-02 tokens_estimated: 704 verification: method: substring_match claims: 10 passed: 10 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_boxer_arrhythmogenic_right_ventricular_cardiomyopathy_dog/01_companion_breed_health_boxer_arrhythmogenic_right_ventricular_cardiomyopathy_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Boxer — Arrhythmogenic right ventricular cardiomyopathy (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000878/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Boxer — Arrhythmogenic right ventricular cardiomyopathy (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Boxer (Dog)Disorder: Arrhythmogenic right ventricular cardiomyopathyMode of inheritance: MultifactorialSummary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease characterized by monomorphic ventricular arrhythmias, syncope, and sudden cardiac death in Boxer dogs. Because the presenting sign can be sudden death, many dogs die without a diagnosis. Pathologic changes in the heart include dilation of the right ventricle and replacement of myocardial tissue with fibrous and fatty infiltrates. The mode of inheritance appears to be autosomal dominant with incomplete penetrance. A causative mutation has been identified in STRN. Edited by Meg Sleeper, VMD and Vicki N. Meyers-llen, VMD, PhD, Dipl. ACT Holdt et al. (2022) describe occurrence of arrhythmogenic right ventricular cardiomyopathy in Bulldogs. Genetic testing of five cases revealed that the representative Bulldogs from this study did not have the striatin mutation that has been previously documented in Boxers.Clin feat: Signs include monomorphic ventricular arrhythmias, syncope, and sudden cardiac death. Magnetic resonance imaging (MRI) demonstrates right ventricular dilation and aneurysms, reduced right ventricular ejection fraction, and bright anterolateral and/or infundibular ventricular signals corresponding with an infiltration of fatty tissue (Meurs et al, 2010). Dogs homozygous for the STRN mutation had, on average, more ventricular premature contractions (VPCs) than heterozygous dogs (Meurs et al., 2010). Although STRN is also highly expressed in neural tissue, affected dogs have no apparent neurologic deficits (Meurs et al., 2010).Defect: yesPathology: Frequent left bundle branch block morphology ventricular premature complexes cause the clinical signs (Meurs et al., 2010). The disorder causes a gradual and progressive right (and sometimes left) ventricular loss of muscle which is replaced with fat and fibrous tissue. Lesions include a thin right ventricular free wall, aneurysms, and myocyte loss starting at the epicardium (Basso et al., 2004).Prevalence: Prevalence is thought to be very high in the USA, and it may also be prevalent in the Netherlands. True prevalence is unknown because many dogs likely die without a diagnosis.Control: Breeding of affected dogs is not recommended.Gen test: In assessing the results of Cattanach et al. (2015), Sargan (2015) discussed the pitfalls of basing a DNA test on a mutation that has been thought to be the cause of a monogenic disease and has been treated as such in two commercial genetic testing laboratories [but which] is in fact not causal, but simply linked to the disease. DNA testing laboratories should heed this advice.
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIA entry symbol: ARVC (no structured Phene_Gene link)
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1994. Right Ventricular Cardiomyopathy in a Dog. Journal of Veterinary Internal Medicine — PubMed:PMID7983631 — OMIA Phene_Article / Article
- 1995. Isolated right ventricular cardiomyopathy in a dog. Journal of the American Veterinary Medical Association — PubMed:PMID7601695 — OMIA Phene_Article / Article
- 1999. Familial ventricular arrhythmias in boxers. Journal of Veterinary Internal Medicine — PubMed:PMID10499727 — OMIA Phene_Article / Article
- 2004. Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs: a new animal model of human disease. Circulation — PubMed:PMID14993138 | DOI:10.1161/01.CIR.0000118494.07530.65 — OMIA Phene_Article / Article
- 2007. Desmosomal gene evaluation in Boxers with arrhythmogenic right ventricular cardiomyopathy. Am J Vet Res — PubMed:PMID18052738 | DOI:10.2460/ajvr.68.12.1338 — OMIA Phene_Article / Article
- 2008. Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency. J Vet Cardiol — PubMed:PMID18515204 | DOI:10.1016/j.jvc.2008.04.003 — OMIA Phene_Article / Article
- 2009. Temporal variability of ventricular arrhythmias in Boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med — PubMed:PMID19678888 | DOI:10.1111/j.1939-1676.2009.0366.x — OMIA Phene_Article / Article
- 2010. Genome-wide association identifies a deletion in the 3' untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy. Hum Genet — PubMed:PMID20596727 | DOI:10.1007/s00439-010-0855-y — OMIA Phene_Article / Article
- 2008. Magnetic resonance imaging of right ventricular morphology and function in boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med — PubMed:PMID19192154 | DOI:10.1111/j.1939-1676.2008.0266.x — OMIA Phene_Article / Article
- 2010. ECG of the month. Arrhythmogenic right ventricular cardiomyopathy in a Boxer. J Am Vet Med Assoc — PubMed:PMID20433394 | DOI:10.2460/javma.236.9.961 — OMIA Phene_Article / Article
- 2006. The use of an implantable cardioverter defibrillator in a Boxer Dog to control clinical signs of arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med — PubMed:PMID17063723 — OMIA Phene_Article / Article
- 1991. Boxer cardiomyopathy. A review of the long-term benefits of antiarrhythmic therapy. Vet Clin North Am Small Anim Pract — PubMed:PMID1949503 | DOI:10.1016/s0195-5616(91)50107-8 — OMIA Phene_Article / Article
- (18 additional references in OMIA)
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:107970 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."