--- license: permission_granted topic_id: companion_breed_health_black_and_tan_coonhound_omia1422_dog category: companion-breed-health title: "Black and Tan Coonhound — Pelger-Huet anomaly (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/black_and_tan_coonhound_omia1422_1422.txt date_parsed: 2026-08-02 tokens_estimated: 368 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_black_and_tan_coonhound_omia1422_dog/01_companion_breed_health_black_and_tan_coonhound_omia1422_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Black and Tan Coonhound — Pelger-Huet anomaly (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000783/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Black and Tan Coonhound — Pelger-Huet anomaly (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Black and Tan Coonhound (Dog)Disorder:Summary: Human Pelger-Huët anomaly is caused by heterozygous variants in the LBR gene and characterized by hyposegmentation of granulocytes. Bi-allelic loss of function of the LBR gene in humans results in Greenberg skeletal dysplasia, a severe condition involving prenatal lethality. All literature before 2023 hypothesized that dogs with hyposegmentation of granulocytes represent true homologs of the human Pelger-Huët anomaly, but the underlying causal genetic variant in dogs was unknown. Lourdes Frehner et al. (2023) demonstrated that a common form of hyposegmentation of granulocytes in dogs is actually caused by a variant in the LMBR1L gene (OMIA:002700-9615). Lourdes Frehner et al. (2023) proposed to reserve the term Pelger-Huët anomaly for LBR-related forms of hyposegmentation of granulocytes. At this time, it is not clear whether a true LBR-related form of PHA has ever been observed in dogs.Clin feat: PHA is a leucocyte development-disorder, in which granulocytes and monocytes show hyposegmentation of the nuclei with a mature, coarse chromatin pattern (Latimer et al. 2000). Those changes are without any clinical relevance, but frequently lead to misdiagnosis as marked left shift, which is normally caused by inflammation, preleucaemic syndrome or drug induced changes in leucocyte morphology.Defect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIA entry symbol: PHA (no structured Phene_Gene link)
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1979. Studies of the Pelger-Huet anomaly in Foxhounds. American Journal of Pathology — PubMed:PMID464021 — OMIA Phene_Article / Article
- 1997. Pelger-Huet anomaly in an Addisonian. Canine Practice — OMIA Phene_Article / Article
- 2000. Pelger-Huet anomaly in Australian shepherds: 87 cases (1991-1997). Comparative Haematology International — OMIA Phene_Article / Article
- 1967. [Pelger-Huet nuclear anomaly in leukocytes in a dog]. Berl Munch Tierarztl Wochenschr — PubMed:PMID5628116 — OMIA Phene_Article / Article
- 2011. Pelger-Huët anomaly in two related mixed-breed dogs. J Vet Diagn Invest — PubMed:PMID21908340 | DOI:10.1177/1040638711407891 — OMIA Phene_Article / Article
- 2011. Congenital Pelger-Huët anomaly in a Danish/Swedish Farmdog: case report. Acta Vet Scand — PubMed:PMID21362186 | DOI:10.1186/1751-0147-53-14 — OMIA Phene_Article / Article
- 1989. Leukocyte function in Pelger-Huët anomaly of dogs. J Leukoc Biol — PubMed:PMID2649629 | DOI:10.1002/jlb.45.4.301 — OMIA Phene_Article / Article
- 2023. Autosomal recessive hyposegmentation of granulocytes in Australian Shepherd Dogs indicates a role for LMBR1L in myeloid leukocytes. PLoS Genet — PubMed:PMID37347778 | DOI:10.1371/journal.pgen.1010805 — OMIA Phene_Article / Article
- 2025. Prevalence of hyposegmentation of granulocytes/Pelger-Huët anomaly in different canine breeds: a Bayesian approach. Front Vet Sci — PubMed:PMID40567546 | DOI:10.3389/fvets.2025.1602474 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:169400 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."