--- license: permission_granted topic_id: companion_breed_health_belgian_shepherd_dog_omia4314_dog category: companion-breed-health title: "Belgian Shepherd Dog — Cardiomyopathy and juvenile mortality (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/belgian_shepherd_dog_omia4314_4314.txt date_parsed: 2026-08-02 tokens_estimated: 233 verification: method: substring_match claims: 7 passed: 7 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_belgian_shepherd_dog_omia4314_dog/01_companion_breed_health_belgian_shepherd_dog_omia4314_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Belgian Shepherd Dog — Cardiomyopathy and juvenile mortality (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA002256/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Belgian Shepherd Dog — Cardiomyopathy and juvenile mortality (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Belgian Shepherd Dog (Dog)Disorder:Mode of inheritance: Autosomal recessiveClin feat: The clinical phenotype is unspecific and variable. In the study of Gurtner et al. (2020), three affected puppies were studied, which all died at 8 weeks of age. A few days prior to death they showed various clinical signs such as vomiting and dyspnea (n = 2) or lethargy and muscle twitching (n = 1) (Gurtner et al. 2020).Defect: yesPathology: Cardiomyocytes of affected puppies were swollen and pale, and the sarcoplasm around the nucleus was dispersed by finely granular material (Gurtner et al. 2020). The authors concluded: The cause of disease and death were likely due to the degenerative changes in the heart, leading to myocardial failure.Prevalence: Gurtner et al. (2020): The carrier frequency was 27.2% in the tested Belgian Shepherd dogs
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 388252268 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2020. YARS2 missense variant in Belgian Shepherd dogs with cardiomyopathy and juvenile mortality. Genes (Basel) — PubMed:PMID32183361 | DOI:10.3390/genes11030313 — OMIA Phene_Article / Article
- 2023. Recessive aminoacyl-tRNA synthetase disorders: lessons learned from in vivo disease models. Front Neurosci — PubMed:PMID37274208 | DOI:10.3389/fnins.2023.1182874 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:613561 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:610957 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."