Basset Hound — Weill-Marchesani-like syndrome; goniodysgenesis (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_basset_hound_weill_marchesani_like_syndrome_goniodysgenesis_dog category: companion-breed-health title: "Basset Hound — Weill-Marchesani-like syndrome; goniodysgenesis (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/basset_hound_weill_marchesani_like_syndrome_goniodysgenesis_3797.txt date_parsed: 2026-08-02 tokens_estimated: 80 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_basset_hound_weill_marchesani_like_syndrome_goniodysgenesis_dog/01_companion_breed_health_basset_hound_weill_marchesani_like_syndrome_goniodysgenesis_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Basset Hound — Weill-Marchesani-like syndrome; goniodysgenesis (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001976/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Basset Hound — Weill-Marchesani-like syndrome; goniodysgenesis (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: Basset Hound (Dog)
• Disorder: Weill-Marchesani-like syndrome; goniodysgenesis
• Mode of inheritance: Autosomal recessive
• Summary: see also OMIA 000588-9615 : Lens luxation in Canis lupus familiaris
• Defect: yes

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: Entrez Gene ID 26591637 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2015. Two independent mutations in ADAMTS17 are associated with primary open angle glaucoma in the Basset Hound and Basset Fauve de Bretagne breeds of dog. PLoS One — PubMed:PMID26474315 | DOI:10.1371/journal.pone.0140436 — OMIA Phene_Article / Article
• 2015. Genetics of canine primary glaucomas. Vet Clin North Am Small Anim Pract — PubMed:PMID26277300 | DOI:10.1016/j.cvsm.2015.06.003 — OMIA Phene_Article / Article
• 2016. Correction: Two independent mutations in ADAMTS17 are associated with primary open angle glaucoma in the Basset Hound and Basset Fauve de Bretagne breeds of dog. PLoS One — PubMed:PMID27192202 | DOI:10.1371/journal.pone.0156192 — OMIA Phene_Article / Article
• 2015. Definition, classification, and pathophysiology of canine glaucoma. Vet Clin North Am Small Anim Pract — PubMed:PMID26456751 | DOI:10.1016/j.cvsm.2015.06.002 — OMIA Phene_Article / Article
• 2017. Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol — PubMed:PMID27681326 | DOI:10.1177/0300985816666611 — OMIA Phene_Article / Article
• 2018. Evaluation of ADAMTS17 in Chinese Shar-Pei with primary open-angle glaucoma, primary lens luxation, or both. Am J Vet Res — PubMed:PMID29287154 | DOI:10.2460/ajvr.79.1.98 — OMIA Phene_Article / Article
• 2019. Glaucoma-causing ADAMTS17 mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma. Canine Genet Epidemiol — PubMed:PMID31131111 | DOI:10.1186/s40575-019-0071-6 — OMIA Phene_Article / Article
• 2017. Open-angle glaucoma in the Petit Basset Griffon Vendeen. Vet Ophthalmol — PubMed:PMID26945802 | DOI:10.1111/vop.12369 — OMIA Phene_Article / Article
• 2015. A novel genome-wide association study approach using genotyping by exome sequencing leads to the identification of a primary open angle glaucoma associated inversion disrupting ADAMTS17. PLoS One — PubMed:PMID26683476 | DOI:10.1371/journal.pone.0143546 — OMIA Phene_Article / Article
• 2015. Ocular Disorders Presumed to be Inherited in Purebred Dogs (“The Blue Book”), 8th edition — OMIA Phene_Article / Article
• 2017. Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease. Sci Rep — PubMed:PMID28176809 | DOI:10.1038/srep41871 — OMIA Phene_Article / Article
• 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article
• (1 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:613195 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:607511 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."