--- license: permission_granted topic_id: companion_breed_health_arab_horse_omia483_horse category: companion-breed-health title: "Arab (Horse) — Curly coat (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump." source_file: pdf-raw/breed-health/arab_horse_omia483_483.txt date_parsed: 2026-08-23 tokens_estimated: 250 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-23 recovered: false path: companion-breed-health/companion_breed_health_arab_horse_omia483_horse/01_companion_breed_health_arab_horse_omia483_horse.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Arab (Horse) — Curly coat (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000245/9796/" retrieved: "2026-08-23" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Arab (Horse) — Curly coat (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Arab (Horse)Disorder:Mode of inheritance: Morgenthaler et al (2017): in North American horses, the most frequent Curly coat phenotype is described as autosomal dominant (Crd) [Sponenberg, 1990], whereas recessive forms have been reported to segregate in the Quarter Horse, Arabian, Appaloosa, Missouri Fox Trotter, Tennessee Walking Horse, Paint, Morgan and Paso Fino breeds [Sponenberg, 1990] as well as in French Percheron horses [Blakeslee et al., 1943].Summary: Information relating to curly coat in horses due to variants in emKRT25/em and emSP6nbsp;/emwas previously listed here but has been moved to gene specific entries [13/02/2026] - seenbsp;a href=../../../../../../OMIA003039/9796/OMIA:003039-9796/a : Curly coat, KRT25-related in Equus caballus (domestic horse) and a href=../../../../../../OMIA002175/9796/OMIA:002175-9796/a : Curly coat, SP6-related in Equus caballus (domestic horse).Defect: no
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIA molecular-genetics note: For information on likely causal variants in <em>KRT25</em> and <em>SP6 </em>which were previously listed here see <a href="../../../../../../OMIA003039/9796/">OMIA:003039-9796</a> : Curly coat, KRT25-related in Equus caballus (domestic horse) and <a href="../../../../../../OMIA002175/9796/">OMIA:002175-9796</a> : Curly coat, SP6-related in Equus caballus (domestic horse).
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1940. Inheritance of curliness in the horse. C.R. (Doklady) Academy of Science U.R.S.S., N.S. — OMIA Phene_Article / Article
- 1990. Dominant Curly Coat in Horses. Genetics Selection Evolution — OMIA Phene_Article / Article
- 2016. Rare phenotypes in domestic animals: unique resources for multiple applications. Anim Genet — PubMed:PMID26662214 | DOI:10.1111/age.12393 — OMIA Phene_Article / Article
- 2017. A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse. Genet Sel Evol — PubMed:PMID29141579 | DOI:10.1186/s12711-017-0359-5 — OMIA Phene_Article / Article
- 1989. Myth and mystery: the curly horse in America. New York: C.S. Fund Inc. — OMIA Phene_Article / Article
- 1943. Curly coat of horses. Journal of Heredity — OMIA Phene_Article / Article
- 2018. An epistatic effect of KRT25 on SP6 is involved in curly coat in horses. Sci Rep — PubMed:PMID29686323 | DOI:10.1038/s41598-018-24865-3 — OMIA Phene_Article / Article
- 2024. Horse allergy: Curly Horses can mediate immune tolerance. Pneumologie — PubMed:PMID37827498 | DOI:10.1055/a-2101-9533 — OMIA Phene_Article / Article
- 2024. Predicted genetic burden and frequency of phenotype-associated variants in the horse. Sci Rep — PubMed:PMID38600096 | DOI:10.1038/s41598-024-57872-8 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:608245 (type: gene) — OMIA Group_OMIM (via OMIA_ID)