--- license: permission_granted topic_id: companion_breed_health_american_hairless_terrier_recessive_hairlessness_congenital_alopecia_dog category: companion-breed-health title: "American Hairless Terrier — Recessive hairlessness, congenital alopecia (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/american_hairless_terrier_recessive_hairlessness_congenital_alopecia_4005.txt date_parsed: 2026-08-02 tokens_estimated: 529 verification: method: substring_match claims: 7 passed: 7 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_american_hairless_terrier_recessive_hairlessness_congenital_alopecia_dog/01_companion_breed_health_american_hairless_terrier_recessive_hairlessness_congenital_alopecia_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "American Hairless Terrier — Recessive hairlessness, congenital alopecia (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001279/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
American Hairless Terrier — Recessive hairlessness, congenital alopecia (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: American Hairless Terrier (Dog)Disorder: Recessive hairlessness, congenital alopeciaMode of inheritance: Autosomal recessiveSummary: See also a href=https://www.omia.org/OMIA000323/9615/OMIA:000323-9615/a : Ectodermal dysplasia in Canis lupus familiaris (dog) for a different genetic form of hairless dogs due to variants in the emFOXI3/em gene.Clin feat: American Hairless Terrier puppies are born with a sparse downy coat of hair that is lost within the first months of life and not replaced. Whiskers and eyebrows are present (Sponenberg et al., 1988). The 2 Scottish Deerhound puppies reported by Hytönen amp; Lohi (2019) were born with sparse hair, but lost it completely within the first 2 months of life. Parker et al. (2020) identified the condition in an independent Scottish Deerhound family and noted that puppies displayed either a normal, full coat or a sparse and receding coat ... . In those who initially had hair but went bald, the coat progressively thinned early in life and was completely gone by five weeks. Hairless dogs in both breeds are described as otherwise generally healthy (Parker et al., 2017; Hytönen amp; Lohi, 2019; Parker et al., 2020), but hairlessness is considered non desirable in the Scottish Deerhound.Defect: yesPrevalence: Hytönen and Lohi (2019) genotyped the SGK3:c.137_138insT variant . . . in a cohort of Scottish Deerhounds (n = 66) containing two affected dogs, two unaffected dogs, which had produced affected progeny, and 62 other unaffected dogs from our biobank. Both affected dogs were homozygous for the variant and the two obligate carriers were heterozygous, while the rest of the dogs were either heterozygous (n = 6) or homozygous for the wild-type allele (n = 56). These results demonstrate a full segregation of the variant with the disease and indicate a 12% carrier frequency in the studied cohort. We screened the variant also in a related breed, Irish Wolfhound (n = 91), but did not find any carriers, suggesting a breed-specific variant in SD population.
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 388252519 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Parker et al. (2017) identified a likely causal mutation ("SGK3^Val96GlyfsTer50"): a "deletion [that] removes four bases (TTAG) from chr29 : 16366702–16366705 within exon 4 of the serum/glucocorticoid regulated kinase family member 3 gene (SGK3). This deletion alters the reading frame of the protein at amino acid 96 creating a new protein sequence for 50 amino acids and a premature stop at amino a…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2017. The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci — PubMed:PMID27994129 | DOI:10.1098/rstb.2015.0488 — OMIA Phene_Article / Article
- 1988. American hairless terriers: a recessive gene causing hairlessness in dogs. J Hered — PubMed:PMID3367039 | DOI:10.1093/oxfordjournals.jhered.a110451 — OMIA Phene_Article / Article
- 2019. A frameshift insertion in SGK3 leads to recessive hairlessness in Scottish Deerhounds: a candidate gene for human alopecia conditions. Hum Genet — PubMed:PMID30927068 | DOI:10.1007/s00439-019-02005-9 — OMIA Phene_Article / Article
- 2020. Whole genome analysis of a single Scottish Deerhound dog family provides independent corroboration that a SGK3 coding variant leads to hairlessness. G3 (Bethesda) — PubMed:PMID31727632 | DOI:10.1534/g3.119.400885 — OMIA Phene_Article / Article
- 2022. Genetics of inherited skin disorders in dogs. Vet J — PubMed:PMID34861369 | DOI:10.1016/j.tvjl.2021.105782 — OMIA Phene_Article / Article
- 2023. Canine noninflammatory alopecia: An approach to its classification and a diagnostic aid. Vet Pathol — PubMed:PMID37191329 | DOI:10.1177/03009858231170295 — OMIA Phene_Article / Article
- 2006. An overview on congenital alopecia in domestic animals. Vet Dermatol — PubMed:PMID17083571 | DOI:10.1111/j.1365-3164.2006.00544.x — OMIA Phene_Article / Article
- 2023. Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture. Genome Biol — PubMed:PMID37582787 | DOI:10.1186/s13059-023-03023-7 — OMIA Phene_Article / Article
- 2025. Analysis of canine gene constraint identifies new variants for orofacial clefts and stature. Genome Res — PubMed:PMID40127928 | DOI:10.1101/gr.280092.124 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:607591 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."