--- license: permission_granted topic_id: companion_breed_health_american_bobtail_manx_tailllessness_cat category: companion-breed-health title: "American Bobtail — Manx tailllessness (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/american_bobtail_manx_tailllessness_3630.txt date_parsed: 2026-08-02 tokens_estimated: 206 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_american_bobtail_manx_tailllessness_cat/01_companion_breed_health_american_bobtail_manx_tailllessness_cat.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "American Bobtail — Manx tailllessness (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000975/9685/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
American Bobtail — Manx tailllessness (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: American Bobtail (Cat)Disorder: Manx tailllessnessMode of inheritance: Autosomal dominant + recessive lethalClin feat: As summarised by Buckingham et al. (2013), The variable tail length of the Manx recapitulates that of tail variation in mice and can be categorized into four specific tail-length phenotypes. These range from absence of the tail (anury) (i.e., rumpy), a minimal tail (i.e., rumpy-riser) that is apparent only by palpation, a short tail (i.e., stumpy), to a full tail (i.e., longie) . . . (Howell and Siegel 1963; Robinson 1993; Todd 1963). The length of the tail is proportional to the number of caudal vertebrae, with complete absence of caudal vertebrae found only in cats with the rumpy phenotype.Defect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 389727276 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Following the comparative candidate gene strategy, based on similar phenotypes in mice and dogs known to be due to mutations in the T gene (now called TBXT) that encodes brachyury (a transcription factor which regulates notochord differentiation), Buckingham et al. (2013) characterised and "sequenced the T gene in several independent lineages of Manx cats from both the US and the Isle of Man and i…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1971. A congenital defect in the spinal cord of the Manx cat. Vet Pathol — PubMed:PMID4950726 | DOI:10.1177/030098587100800305 — OMIA Phene_Article / Article
- 1963. Independent assortment of Manx and three coat colour mutants in the domestic cat. J Hered — PubMed:PMID14098315 | DOI:10.1093/oxfordjournals.jhered.a107263 — OMIA Phene_Article / Article
- 1974. Congenital defects of the caudal vertebral column and spinal cord in Manx cats. J Am Vet Med Assoc — PubMed:PMID4813411 — OMIA Phene_Article / Article
- 1963. Phenotypic variability of taillessness in Manx cats. J Hered — PubMed:PMID14057865 | DOI:10.1093/jhered/54.4.167 — OMIA Phene_Article / Article
- 1964. The inheritance of taillessness of Manx cats. Journal of Cat Genetics — OMIA Phene_Article / Article
- 1961. The inheritance of taillessness in Manx cats. Journal of Heredity — OMIA Phene_Article / Article
- 1993. Expressivity of the Manx Gene in Cats. J Hered — PubMed:PMID8228170 | DOI:10.1093/oxfordjournals.jhered.a111311 — OMIA Phene_Article / Article
- 2002. Analysis of the inheritance of taillessness in the Baikuzino population of cats from Udmurtia. Russian Journal of Genetics — OMIA Phene_Article / Article
- 2009. Surgical management of vertebral malformation in a Manx cat. J Feline Med Surg — PubMed:PMID19097923 | DOI:10.1016/j.jfms.2008.11.005 — OMIA Phene_Article / Article
- 1969. Congenital anomalies of the lower spine and spinal cord in Manx cats. J Pathol — PubMed:PMID4900931 | DOI:10.1002/path.1710970212 — OMIA Phene_Article / Article
- 1964. The Manx factor in domestic cats. A possible genetic basis for expressivity of taillessness and other associated anomalies. J Hered — PubMed:PMID14209098 — OMIA Phene_Article / Article
- 1966. Morphological effects of the Manx factor in cats. J Hered — PubMed:PMID6006809 | DOI:10.1093/oxfordjournals.jhered.a107474 — OMIA Phene_Article / Article
- (21 additional references in OMIA)
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:601397 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:615709 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:182940 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."