公告168 药物饲料添加剂目录 × FDA ADE：盐酸环丙沙星、盐酸小檗碱预混剂（Ciprofloxacin Hydrochloride and Berberine Hydrochloride Premix）
Cross-reference between China's veterinary medicinal feed-additive directory (农业部公告第168号《饲料药物添加剂使用规范》) and the US FDA CVM adverse-event (ADE) report database (openFDA animalandveterinary/event.json). This is a structural link, not a clinical assertion.
Directory entry (公告168, first-hand MOFCOM PDF)
- 中文名：盐酸环丙沙星、盐酸小檗碱预混剂
- English name：Ciprofloxacin Hydrochloride and Berberine Hydrochloride Premix
- 有效成分（active ingredient）：ciprofloxacin berberine（盐酸环丙沙星和盐酸小檗碱）
- 所属目录：附录二（防治用，须遵守休药期）
- 适用动物：鳗鱼
- 作用与用途：用于治疗鳗鱼细菌性疾病。
OpenFDA ADE cross-reference
- OpenFDA ADE 报告数：297（截至 2026-08-16，openFDA animalandveterinary/event.json 中以“ciprofloxacin”为活性成分检出的不良事件报告总数，报告级聚合）。
- 对应站内 FDA ADE topic：[ade_ciprofloxacin_adverse_events](../../ade/ade_ciprofloxacin_adverse_events/01_ciprofloxacin.md)
Honest scope note
公告168 was repealed for growth-promotion use by 公告194 (2019/2020); its directory remains the authoritative list of veterinary medicinal feed additives. OpenFDA data is US-reported and may not include China-specific products or trade names; an ADE count reflects spontaneous reporting volume, not incidence or per-animal risk. Active-ingredient→OpenFDA term mapping is editorial. Source: MOFCOM PDF cn_medical_feed_additive_dir_ann168_mofcom.pdf + openFDA slice cn_ade_crossref_2026-08-16.json (both pulled 2026-08-16).