Zonisamide — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Zonisamide is a veterinary active ingredient.
Total reports
Zonisamide: 312
Reports by species (top entries)
- Dog 302
- Cat 9
- Human 1
Top reported reactions (VEDDRA terms, top entries)
- Seizure NOS 113
- Vomiting 42
- Lethargy (see also Central nervous system depression in 'Neurological') 31
- Death by euthanasia 30
- Diarrhoea 29
- Ataxia 25
- Lethargy (see also Central nervous system depression in Neurological) 23
- Anorexia 21
- Lack of efficacy - NOS 20
- Not eating 20
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).