Trilostane — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Trilostane is a veterinary active ingredient.
Total reports
Trilostane: 12001
Reports by species (top entries)
- Dog 11720
- Human 46
- Cat 10
- Horse 1
- Other 1
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 1995
- Lethargy (see also Central nervous system depression in 'Neurological') 1973
- Hyperkalaemia 1742
- Elevated serum alkaline phosphatase (SAP) 1687
- Weight loss 1479
- Underdose 1430
- Diarrhoea 1425
- Elevated alanine aminotransferase (ALT) 1372
- Elevated blood urea nitrogen (BUN) 1121
- Decreased appetite 1098
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).