trifexis — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-08-16. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. "trifexis" is a name as filed in the drug active-ingredient field of these reports (may be a generic ingredient or a product/brand name as reported).
Total reports
trifexis: 91
Reports by species (top entries)
- Dog 91
Top reported reactions (VEDDRA terms, top entries)
- Lack of efficacy (endoparasite) - heartworm 57
- Seizure NOS 7
- Lethargy (see also Central nervous system depression in 'Neurological') 6
- Ataxia 5
- Diarrhoea 4
- Death by euthanasia 3
- Drug dose administration interval too long 3
- Medication error NOS 3
- Shaking 3
- Vomiting 3
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json (openFDA animalandveterinary/event.json, pulled 2026-08-16).