Theophylline — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Theophylline is a active ingredient.
Total reports
Theophylline: 181
Reports by species (top entries)
- Dog 173
- Cat 8
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 36
- Lethargy (see also Central nervous system depression in 'Neurological') 29
- Cough 21
- Death by euthanasia 21
- Abnormal radiograph finding 17
- Decreased appetite 17
- Other abnormal test result NOS 16
- Behavioural disorder NOS 15
- Diarrhoea 15
- Emesis 15
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b19.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).