Spironolactone — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Spironolactone is a veterinary active ingredient.
Total reports
Spironolactone: 297
Reports by species (top entries)
- Dog 248
- Cat 22
- Human 4
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 64
- Diarrhoea 37
- Elevated blood urea nitrogen (BUN) 34
- Death by euthanasia 33
- Lethargy (see also Central nervous system depression in 'Neurological') 33
- Anorexia 27
- Lack of efficacy - NOS 27
- Death 25
- Elevated creatinine 24
- Decreased appetite 21
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b6.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).