Spinosad — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Spinosad is a spinosyn ectoparasiticide (flea).
Total reports
Spinosad: 212330
Reports by species (top entries)
- Dog 185564
- Cat 11867
- Human 454
- Other 16
- 15
- Other Canids 14
Top reported reactions (VEDDRA terms, top entries)
- Emesis 60054
- Vomiting 51506
- Lethargy (see also Central nervous system depression in 'Neurological') 23417
- Lack of efficacy (ectoparasite) - flea 21071
- UNPALATABLE 17115
- Lack of efficacy - NOS 13957
- Diarrhoea 8985
- INEFFECTIVE, HEARTWORM LARVAE 5672
- Seizure NOS 5429
- Lack of efficacy (endoparasite) - heartworm 5093
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).