Sirolimus — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Sirolimus is a active ingredient.
Total reports
Sirolimus: 39
Reports by species (top entries)
- Cat 38
- Dog 1
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 12
- Weight loss 9
- Congestive heart failure 6
- Elevated alanine aminotransferase (ALT) 6
- Lethargy (see also Central nervous system depression in Neurological) 6
- Abnormal radiograph finding 5
- Abnormal ultrasound finding 5
- Administration error NOS 5
- Decreased appetite 5
- Hypertension 5
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b25.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).