sarolaner — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. sarolaner is a isoxazoline ectoparasiticide (flea/tick).
Total reports
sarolaner: 79692
Reports by species (top entries)
- Dog 67742
- Cat 8207
- Human 143
- Rabbit 3
- Bobcat 2
- Lynx 2
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 13516
- Seizure NOS 7249
- Lack of efficacy (bacteria) - Borrelia 6736
- Lack of efficacy (endoparasite) - heartworm 6178
- Diarrhoea 5497
- Lack of efficacy (endoparasite) - hookworm 4379
- Lack of efficacy (ectoparasite) - tick NOS 4305
- Lethargy (see also Central nervous system depression in 'Neurological') 4241
- Lack of efficacy (endoparasite) - roundworm NOS 3464
- Lack of efficacy (ectoparasite) - flea 3404
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).