Pyriproxyfen — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Pyriproxyfen is a active ingredient.
Total reports
Pyriproxyfen: 1452
Reports by species (top entries)
- Dog 956
- Cat 487
- Human 6
- Rabbit 1
Top reported reactions (VEDDRA terms, top entries)
- Lack of efficacy (ectoparasite) - flea 378
- Pruritus 298
- Lethargy (see also Central nervous system depression in 'Neurological') 165
- Vomiting 150
- Behavioural disorder NOS 138
- Diarrhoea 85
- Anorexia 69
- Application site pruritus 65
- Seizure NOS 61
- Other abnormal test result NOS 58
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b10.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).