Pyrantel — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Pyrantel is a veterinary active ingredient.
Total reports
Pyrantel: 251645
Reports by species (top entries)
- Dog 229742
- Cat 1996
- Horse 946
- Human 244
- Other 40
- Other Canids 10
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 37796
- INEFFECTIVE, HEARTWORM LARVAE 35856
- Lack of efficacy (endoparasite) - hookworm 31833
- Lack of efficacy (endoparasite) - heartworm 28958
- Digestive tract disorder NOS 16840
- Diarrhoea 16144
- INEFFECTIVE, ASCARIDS NOS 12018
- Cardiac disorder NOS 10073
- Lethargy (see also Central nervous system depression in 'Neurological') 9657
- Lack of efficacy (endoparasite) - roundworm NOS 9213
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).