Pentosan Polysulfate Sodium — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Pentosan Polysulfate Sodium is a active ingredient.
Total reports
Pentosan Polysulfate Sodium: 194
Reports by species (top entries)
- Horse 181
- Dog 9
- Human 1
Top reported reactions (VEDDRA terms, top entries)
- Injection site swelling 64
- Hives (see also Skin) 26
- Injection site hair change 23
- Injection site pain 20
- Reluctant to move 13
- Lethargy (see also Central nervous system depression in Neurological) 12
- Colic 10
- Injection site reaction NOS 10
- Fever 8
- Injection site hair loss 8
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b18.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).