Milk Thistle — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Milk Thistle is a active ingredient.
Total reports
Milk Thistle: 153
Reports by species (top entries)
- Dog 146
- Cat 5
- Other Birds 1
Top reported reactions (VEDDRA terms, top entries)
- Lethargy (see also Central nervous system depression in 'Neurological') 37
- Vomiting 32
- Elevated alanine aminotransferase (ALT) 26
- Elevated serum alkaline phosphatase (SAP) 23
- Anorexia 18
- Diarrhoea 18
- Other abnormal test result NOS 17
- Seizure NOS 17
- Panting 16
- Elevated liver enzymes 15
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b19.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).