Milbemycin oxime — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Milbemycin oxime is a veterinary active ingredient.
Total reports
Milbemycin oxime: 193925
Reports by species (top entries)
- Dog 179119
- Cat 559
- Human 308
- 13
- Other Canids 10
- Other 6
Top reported reactions (VEDDRA terms, top entries)
- Emesis 43026
- Vomiting 39181
- Lethargy (see also Central nervous system depression in 'Neurological') 22021
- Lack of efficacy (endoparasite) - heartworm 14080
- UNPALATABLE 13788
- Lack of efficacy - NOS 13057
- Diarrhoea 10844
- INEFFECTIVE, HEARTWORM LARVAE 9084
- Lack of efficacy (ectoparasite) - flea 7654
- Lack of efficacy (endoparasite) - hookworm 7561
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).