Methylprednisolone — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Methylprednisolone is a veterinary active ingredient.
Total reports
Methylprednisolone: 2599
Reports by species (top entries)
- Cat 1616
- Dog 699
- Horse 104
- Other 5
- Human 2
- Cattle 1
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 327
- Anorexia 279
- Lethargy (see also Central nervous system depression in 'Neurological') 254
- Death 251
- Lack of efficacy - NOS 222
- Weight loss 199
- Death by euthanasia 184
- Hyperglycaemia 154
- Other abnormal test result NOS 150
- Ataxia 142
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b5.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).