Leptospirosis Vaccine — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Leptospirosis Vaccine is a vaccine/biologic.
Total reports
Leptospirosis Vaccine: 497
Reports by species (top entries)
- Dog 497
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 152
- Lethargy (see also Central nervous system depression in Neurological) 83
- Diarrhoea 67
- Not eating 52
- Other abnormal test result NOS 52
- Lethargy (see also Central nervous system depression in 'Neurological') 48
- Elevated alanine aminotransferase (ALT) 47
- Death by euthanasia 36
- Emesis (multiple) 35
- Anorexia 31
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b13.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).