Grapiprant — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Grapiprant is a veterinary active ingredient.
Total reports
Grapiprant: 8225
Reports by species (top entries)
- Dog 7556
- Cat 15
- Human 13
- Pig 1
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 1429
- Diarrhoea 1257
- Lack of efficacy - NOS 961
- Lethargy (see also Central nervous system depression in 'Neurological') 659
- Elevated alanine aminotransferase (ALT) 509
- Death by euthanasia 479
- Not eating 468
- Decreased appetite 430
- Bloody diarrhoea 392
- Tablets, Abnormal 369
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).