Estriol — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Estriol is a active ingredient.
Total reports
Estriol: 680
Reports by species (top entries)
- Dog 679
- Rat 1
Top reported reactions (VEDDRA terms, top entries)
- Lack of efficacy - NOS 263
- Vaginal swelling 82
- Vomiting 62
- Anorexia 46
- Death by euthanasia 41
- Diarrhoea 40
- Urinary tract infection 32
- Polydipsia 23
- Seizure NOS 23
- Weight loss 23
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b12.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).