Estradiol — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Estradiol is a active ingredient.
Total reports
Estradiol: 201
Reports by species (top entries)
- Cattle 126
- Dog 34
- Human 7
- Cat 2
- Horse 1
- Other 1
Top reported reactions (VEDDRA terms, top entries)
- Death 50
- Increased sexual interest 30
- Behavioural disorder NOS 18
- Accidental exposure 13
- Mammary gland oedema 12
- INEFFECTIVE, WEIGHT INC 11
- Unclassifiable adverse event 11
- Lameness 10
- Lack of efficacy - NOS 9
- Respiratory tract disorder NOS 9
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b18.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).