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FDA ADE reports for Esafoxolaner

ade_esafoxolaner_adverse_events

ade en 2026-07-22

Esafoxolaner — FDA Animal & Veterinary Adverse Event (ADE) Reports

Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Esafoxolaner is a active ingredient.

Total reports

Esafoxolaner: 3082

Reports by species (top entries)

  • Cat 2904
  • Human 41
  • Dog 14
  • Bobcat 1

Top reported reactions (VEDDRA terms, top entries)

  • Lethargy (see also Central nervous system depression in Neurological) 469
  • Vomiting 380
  • Hypersalivation 269
  • Application site hair loss 267
  • Foaming at the mouth 242
  • Drooling 200
  • Accidental exposure 189
  • Lack of efficacy (ectoparasite) - flea 189
  • Ataxia 184
  • Not eating 180

Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b9.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).

Sources

FDA ADE reports for Esafoxolaner (active ingredient) — total reports, species & reaction breakdown
Source document: FDA FAERS / openFDA Animal & Veterinary Event Reports
US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)retrieved 2026-07-22

Verification file: pdf-raw/ade/ade_active_ingredients_2026-07-22_b9.json

Link points to the issuing authority's site; a direct document link is still being verified.

Machine access

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Raw JSON ↗ llm.txt OpenAPI