Esafoxolaner — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Esafoxolaner is a active ingredient.
Total reports
Esafoxolaner: 3082
Reports by species (top entries)
- Cat 2904
- Human 41
- Dog 14
- Bobcat 1
Top reported reactions (VEDDRA terms, top entries)
- Lethargy (see also Central nervous system depression in Neurological) 469
- Vomiting 380
- Hypersalivation 269
- Application site hair loss 267
- Foaming at the mouth 242
- Drooling 200
- Accidental exposure 189
- Lack of efficacy (ectoparasite) - flea 189
- Ataxia 184
- Not eating 180
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b9.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).