Clodronate Disodium — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Clodronate Disodium is a active ingredient.
Total reports
Clodronate Disodium: 313
Reports by species (top entries)
- Horse 304
- Human 2
- Dog 1
Top reported reactions (VEDDRA terms, top entries)
- Elevated creatinine 84
- Elevated blood urea nitrogen (BUN) 77
- Polyuria 67
- Polydipsia 62
- Colic 59
- Hypercalcaemia 35
- Lethargy (see also Central nervous system depression in 'Neurological') 32
- Hyperkalaemia 28
- Pawing 28
- Anorexia 25
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b16.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).