Amitriptyline — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Amitriptyline is a active ingredient.
Total reports
Amitriptyline: 187
Reports by species (top entries)
- Dog 126
- Cat 56
- Human 4
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 47
- Lethargy (see also Central nervous system depression in 'Neurological') 27
- Emesis 19
- Diarrhoea 14
- Pruritus 13
- Behavioural disorder NOS 12
- Lack of efficacy - NOS 12
- Anorexia 11
- Seizure NOS 11
- Elevated alanine aminotransferase (ALT) 10
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b18.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).