Amantadine — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Amantadine is a active ingredient.
Total reports
Amantadine: 477
Reports by species (top entries)
- Dog 472
- Cat 5
Top reported reactions (VEDDRA terms, top entries)
- Death by euthanasia 73
- Lethargy (see also Central nervous system depression in Neurological) 55
- Vomiting 52
- Diarrhoea 50
- Ataxia 40
- Lack of efficacy - NOS 38
- Limb weakness 38
- Polydipsia 37
- Elevated alanine aminotransferase (ALT) 36
- Polyuria 33
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b13.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).