Alprazolam — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Alprazolam is a active ingredient.
Total reports
Alprazolam: 430
Reports by species (top entries)
- Dog 393
- Human 19
- Cat 17
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 72
- Lethargy (see also Central nervous system depression in 'Neurological') 53
- Emesis 47
- Lack of efficacy - NOS 43
- Anxiety 39
- Diarrhoea 34
- Seizure NOS 30
- Death by euthanasia 28
- Other abnormal test result NOS 25
- Elevated alanine aminotransferase (ALT) 24
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b13.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).