The END_STUDY_REC.AnimalHealth sheet in EFSA OpenFoodTox 3.0 (Zenodo record 19388272, DOI 10.5281/zenodo.19388272) contains 382 study-level records covering toxicological effects on livestock and pets. Each row follows the IUCLID 6 OECD Harmonised Template for animal health endpoint studies (49 columns).
Endpoint classification
| Endpoint | Count | Share |
|---|---|---|
| toxic effects on livestock and pets | 382 | 100.0% |
The AdministrativeData.Endpoint field is identical across all 382 records — every entry in this sheet covers the combined endpoint of "toxic effects on livestock and pets". This is the standard IUCLID endpoint descriptor used by EFSA FEEDAP dossiers for subchronic and chronic animal feeding studies, regardless of whether the test species is pet, livestock, or other.
Test species distribution
| Species | Count | Share |
|---|---|---|
other: (species.Other not specified) | 191 | 50.0% |
| swine | 99 | 25.9% |
| horse | 33 | 8.6% |
| turkey | 26 | 6.8% |
| sheep | 23 | 6.0% |
| goat | 4 | 1.0% |
| rabbit | 4 | 1.0% |
| cow | 2 | 0.5% |
Data quality flag: 191 of 382 records (50.0%) carry the literal species value other: with the MaterialsAndMethods.TestAnimals.Species.Other companion field empty. This means EFSA did not specify which specific species (dog, cat, mouse, rat, etc.) was used in half of the animal health studies in the dataset. The species label is not directly recoverable from END_STUDY_REC.AnimalHealth for these 191 records — they would need to be cross-referenced back to the originating dossier via Document UUID → Parent UUID → DOSSIER.Domain.FoodDomain.
Among the records with specified species, livestock dominates: swine (99) + horse (33) + turkey (26) + sheep (23) + goat (4) + cow (2) = 187 records (96.6% of specified species). No dog or cat entries appear in the explicitly-classified species column.
Route of exposure
| Route | Count | Share |
|---|---|---|
other: (route.Other not specified) | 276 | 72.3% |
| (no route recorded) | 57 | 14.9% |
| oral: applied on feed | 34 | 8.9% |
| oral: unspecified | 11 | 2.9% |
| oral: gavage | 3 | 0.8% |
| oral: capsule | 1 | 0.3% |
49 of 382 records (12.8%) specify an oral route via feed or gavage or capsule — the most common path for feed-additive animal health studies. The 276 records with route other: and no further specification represent a data gap similar to the species column.
Duration of treatment
| Duration unit | Count |
|---|---|
| d (days) | 215 |
| (no duration recorded) | 89 |
| wk (weeks) | 78 |
Subchronic studies (90 days / 13 weeks ≈ 215 day-records) dominate over chronic (52-week ≈ 78 week-records), consistent with OECD Test Guideline 408 (90-day rodent oral toxicity) which is the default for feed additive dossiers.
Effect basis distribution (top 15)
| Effect basis | Count |
|---|---|
other: (basis.Other not specified) | 212 |
| food consumption and compound intake | 24 |
| clinical biochemistry | 23 |
| histopathology: non-neoplastic | 23 |
| body weight and weight gain | 19 |
| gross pathology | 17 |
| mortality | 16 |
| organ weights and organ / body weight ratios | 9 |
| food efficiency | 8 |
| clinical signs | 7 |
| haematology | 6 |
| serum/plasma biochemistry | 3 |
| neuropathology | 2 |
| histopathology: neoplastic | 2 |
Standard OECD TG 408 endpoint set: clinical chemistry, histopathology, body weight, food consumption, organ weights. The other: category (212 records) suggests EFSA did not always populate the structured basis field — possibly recorded in basis.Remarks or basis.Other instead.
Pet food relevance
The "toxic effects on livestock and pets" endpoint label explicitly includes pets. However, the dataset's species column only carries 6.0% livestock-specified records — pet species (dog / cat) do not appear in the classified column. Cross-referencing the 191 unclassified-species records back to originating dossiers via Document UUID → DOSSIER.Domain.FoodDomain would be needed to identify which of the 382 records are pet-specific.
Source: toxicology/efsa/OFT3.0_export_repository.xlsx, sheet END_STUDY_REC.AnimalHealth (382 rows × 49 cols). Pet species classification requires parent-dossier join.