EFSA FEEDAP — L-histidine monohydrochloride monohydrate (E. coli CCTCC M 20241089, GM) for all animal species
Source: EFSA FEEDAP scientific opinion, EFSA Journal 2026;24(4):e10032 (DOI 10.2903/j.efsa.2026.10032), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.
Editorial context (read this before using the data point)
This is the EFSA FEEDAP jurisdiction on the amino-acid feed additive L-histidine monohydrochloride monohydrate (E. coli CCTCC M 20241089) — one of four amino-acid safety opinions in this batch (Task L). Read with the efsa nutrient endpoints and AAFCO/FEDIAF amino-acid provisions.
Key findings (paraphrase; numbers and proper nouns verbatim from source)
- Production strain E. coli CCTCC M 20241089 (genetically modified) raises no safety concern — no viable cells or DNA detected in the final product.
- The additive is safe for target species when supplemented in appropriate amounts to the diet according to their nutritional needs.
- The Panel has concerns on amino acids in drinking water.
- It is safe for consumers and for the environment; in the absence of data the Panel cannot conclude on skin/eye irritancy or dermal sensitisation.
- It is an effective source of L-histidine for all non-ruminant species; ruminants need protection from ruminal degradation.
Pet-food relevance
L-histidine is an essential amino acid in cats and dogs. The 'safe when supplemented to nutritional need' conclusion plus the drinking-water caveat are the usable formulator takeaways.
Scope note / honest gap
Paraphrase of an EFSA opinion; source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose. Full strain-characterisation and tolerance statistics are not reproduced.