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EFSA FEEDAP — L-arginine (C. glutamicum CCTCC M 20232577) for all animal species: safe when supplemented to nutritional need; concerns on use in drinking water (EFSA Journal 2026;24(4):e10074)

EFSA_FEEDAP_larginine_safety

efsa 430 tok en 2026-08-06

EFSA FEEDAP — L-arginine (C. glutamicum CCTCC M 20232577) for all animal species

Source: EFSA FEEDAP scientific opinion, EFSA Journal 2026;24(4):e10074 (DOI 10.2903/j.efsa.2026.10074), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.

Editorial context (read this before using the data point)

This is the EFSA FEEDAP jurisdiction on the amino-acid feed additive C. glutamicum CCTCC M 20232577 — one of four amino-acid safety opinions in this batch. Read with the efsa nutrient endpoints and AAFCO/FEDIAF amino-acid provisions.

Key findings (paraphrase; numbers and proper nouns verbatim from source)

  • The additive is considered safe for the target species when supplemented in appropriate amounts to the diet according to their nutritional needs (fermentation with *C. glutamicum* CCTCC M 20232577).
  • The FEEDAP Panel has concerns on the use of L-arginine in water for drinking.
  • Its use in animal nutrition is considered safe for consumers and for the environment.
  • It is regarded as an effective source of the amino acid L-arginine for all non-ruminant species; to be as efficacious in ruminants as in non-ruminants it should be protected from ruminal degradation.
  • On user safety, in the absence of data the Panel cannot conclude on the potential of the additive to be irritant to skin and/or eyes or to be a dermal sensitiser.

Pet-food relevance

L-arginine is a conditionally essential amino acid in cats, dogs and other pets. The explicit 'safe when supplemented to nutritional need' conclusion plus the drinking-water caveat are the usable formulator takeaways; the ruminant-protection note is relevant where pet diets include unprotected rumen-passage coatings.

Scope note / honest gap

Paraphrase of an EFSA opinion; source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose. Full strain-characterisation and toxicity statistics are not reproduced.

Sources

EFSA FEEDAP — L-arginine (C. glutamicum CCTCC M 20232577) for all animal species: safe when supplemented to nutritional need; concerns on use in drinking water (EFSA Journal 2026;24(4):e10074)
Source document: EFSA FEEDAP — L-arginine (C. glutamicum CCTCC M 20232577) for all animal species: safe when supplemented to nutritional need; concerns on use in drinking water (EFSA Journal 2026;24(4):e10074)
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)EFSA Journal 2026;24(4):e10074retrieved 2026-08-06

Verification file: pdf-raw/efsa_l/PMC13126236.xml