Cat (Felis catus) — Hypotrichosis, HR-related (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Cat (Felis catus)Disorder: Hypotrichosis, HR-relatedSummary: " A recently developed breed, the lykoi (a.k.a. werewolf cat), was bred from cats with a sparse hair coat with roaning, implying full color and all white hairs. The lykoi phenotype is a form of hypotrichia, presenting as a significant reduction in the average numbers of follicles per hair follicle group as compared to domestic shorthair cats, a mild to severe perifollicular to mural lymphocytic infiltration in 77% of observed hair follicle groups, and the follicles are often miniaturized, dilated, and dysplastic. . . . The breeding program was established in 2011 by a veterinarian who has constantly monitored health in the cats [http://lykoikitten.com/history/]. No health concerns have been identified in the lykoi other than the lymphocytic mural folliculitis." (Buckley et al., 2020)Clin feat: Buckley et al. (2020): "A recently developed breed of cat, termed the lykoi . . . , presents a unique form of hypotrichia . . . . Lykoi have a significant reduction in the average numbers of follicles per hair follicle group as compared to domestic shorthair cats, a mild to severe perifollicular to mural lymphocytic infiltration in 77% of observed hair follicle groups, and the follicles are often miniaturized, dilated, and dysplastic. Individual hairs of the coat are either normal coloration or all white, producing a roaning effect. The undercoats are sparse."
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 398298751 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Buckley et al. (2020): "Whole genome sequencing was conducted on a single lykoi cat that was a cross between two independently ascertained lineages. Comparison to the 99 Lives dataset of 194 non-lykoi cats suggested two variants in the cat homolog for Hairless (HR) (HR lysine demethylase and nuclear receptor corepressor) as candidate causal gene variants. The lykoi cat was a compound heterozygote …
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2016. Clinical and Histologic Description of Lykoi Cat Hair Coat and Skin. Japanese Journal of Veterinary Dermatology — OMIA Phene_Article / Article
- 2020. Werewolf, there wolf: Variants in Hairless associated with hypotrichia and roaning in the Lykoi cat breed. Genes (Basel) — PubMed:PMID32580512 | DOI:10.3390/genes11060682 — OMIA Phene_Article / Article
- 2021. A domestic cat whole exome sequencing resource for trait discovery. Sci Rep — PubMed:PMID33785770 | DOI:10.1038/s41598-021-86200-7 — OMIA Phene_Article / Article
- 2026. EXPRESS: Clinical, histopathological and genetic features of a cutaneous adnexal polycystic syndrome in Lykoi cats: a prospective study of 10 cases. J Feline Med Surg — PubMed:PMID41482892 | DOI:10.1177/1098612X251414899 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:203655 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:602302 (type: gene) — OMIA Group_OMIM (via OMIA_ID)