{"topic_id":"companion_species_health_hypotrichosis_hr_related_cat","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_hypotrichosis_hr_related_cat\ncategory: companion-species-health\ntitle: \"Cat (Felis catus) — Hypotrichosis, HR-related (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/cat_hypotrichosis_hr_related_4260.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 373\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_hypotrichosis_hr_related_cat/01_companion_species_health_hypotrichosis_hr_related_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Cat (Felis catus) — Hypotrichosis, HR-related (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA002229/9685/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Cat (Felis catus) — Hypotrichosis, HR-related (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Cat (Felis catus)`\n- `Disorder: Hypotrichosis, HR-related`\n- `Summary: \" A recently developed breed, the lykoi (a.k.a. werewolf cat), was bred from cats with a sparse hair coat with roaning, implying full color and all white hairs. The lykoi phenotype is a form of hypotrichia, presenting as a significant reduction in the average numbers of follicles per hair follicle group as compared to domestic shorthair cats, a mild to severe perifollicular to mural lymphocytic infiltration in 77% of observed hair follicle groups, and the follicles are often miniaturized, dilated, and dysplastic. . . . The breeding program was established in 2011 by a veterinarian who has constantly monitored health in the cats [http://lykoikitten.com/history/]. No health concerns have been identified in the lykoi other than the lymphocytic mural folliculitis.\" (Buckley et al., 2020)`\n- `Clin feat: Buckley et al. (2020): \"A recently developed breed of cat, termed the lykoi . . . , presents a unique form of hypotrichia . . . . Lykoi have a significant reduction in the average numbers of follicles per hair follicle group as compared to domestic shorthair cats, a mild to severe perifollicular to mural lymphocytic infiltration in 77% of observed hair follicle groups, and the follicles are often miniaturized, dilated, and dysplastic. Individual hairs of the coat are either normal coloration or all white, producing a roaning effect. The undercoats are sparse.\"`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 398298751 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Buckley et al. (2020): \"Whole genome sequencing was conducted on a single lykoi cat that was a cross between two independently ascertained lineages. Comparison to the 99 Lives dataset of 194 non-lykoi cats suggested two variants in the cat homolog for Hairless (HR) (HR lysine demethylase and nuclear receptor corepressor) as candidate causal gene variants. The lykoi cat was a compound heterozygote …\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2016. Clinical and Histologic Description of Lykoi Cat Hair Coat and Skin. Japanese Journal of Veterinary Dermatology — OMIA Phene_Article / Article\n- 2020. Werewolf, there wolf: Variants in Hairless associated with hypotrichia and roaning in the Lykoi cat breed. Genes (Basel) — PubMed:PMID32580512 | DOI:10.3390/genes11060682 — OMIA Phene_Article / Article\n- 2021. A domestic cat whole exome sequencing resource for trait discovery. Sci Rep — PubMed:PMID33785770 | DOI:10.1038/s41598-021-86200-7 — OMIA Phene_Article / Article\n- 2026. EXPRESS: Clinical, histopathological and genetic features of a cutaneous adnexal polycystic syndrome in Lykoi cats: a prospective study of 10 cases. J Feline Med Surg — PubMed:PMID41482892 | DOI:10.1177/1098612X251414899 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:203655 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:602302 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Cat (Felis catus) — Hypotrichosis, HR-related (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Cat (Felis catus) — Hypotrichosis, HR-related (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/32580512/","retrieved":"","ref":"PMID 32580512","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":933,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}