Cat (Felis catus) — Vitamin-K-dependent blood coagulation factors deficiency (hereditary; OMIA-verified species predisposition)

Cat (Felis catus) — Vitamin-K-dependent blood coagulation factors deficiency (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Species: Cat (Felis catus)
• Disorder: Vitamin-K-dependent blood coagulation factors deficiency
• Clin feat: Following on from the earlier report by Maddison et al. (1990), Soute et al. (1992) reported that "plasma deficiencies of factors II, VII, IX and X" in Devon Rex cats was associated with "defective gamma-glutamyl-carboxylase, which had a decreased affinity for both vitamin K hydroquinone and propeptide" and speculated that "the low procoagulant activity is the result of a mutation in the vitamin K-dependent carboxylase, leading to poor recognition of the pro-sequence and hence to a poor carboxylation of the various coagulation factors".  

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIA molecular-genetics note: The mutation very reasonably suggested by Soute et al. (1992) to be the cause of the low procoagulant activity, leading to poor carboxylation of the various coagulation factors, has still to be discovered, mainly due to the paucity of cats with this disorder.

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 1990. Vitamin-K-Dependent Multifactor Coagulopathy in Devon Rex Cats. Journal of the American Veterinary Medical Association — PubMed:PMID2272883 — OMIA Phene_Article / Article
• 1992. Congenital Deficiency of All Vitamin-K-Dependent Blood Coagulation Factors Due to a Defective Vitamin-K-Dependent Carboxylase in Devon Rex Cats. Thrombosis and Haemostasis — PubMed:PMID1455398 — OMIA Phene_Article / Article
• 1995. Vitamin K-dependent coagulopathy in a British Devon rex cat. Journal of Small Animal Practice — PubMed:PMID7783435 — OMIA Phene_Article / Article
• 1998. Coagulation abnormalities in 22 cats with naturally occurring liver disease. Journal of Veterinary Internal Medicine — PubMed:PMID9560761 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:277450 (type: trait) — OMIA Group_OMIM (via OMIA_ID)