Horse (Equus caballus) — Shivering (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Horse (Equus caballus)Disorder: ShiveringSummary: Valberg et al. (2023): "Shivers in horses is characterized by abnormal hindlimb movement when walking backward and is proposed to be caused by a Purkinje cell (PC) axonopathy based on histopathology. ... Differences in gene expression between Shivers and control horses were evident in principal component analysis of axon-containing white matter but not PC soma. ... Our findings support axonal degeneration as a characteristic feature of Shivers."
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1999. Clinical and pathologic findings in two draft horses with progressive muscle atrophy, neuromuscular weakness, and abnormal gait characteristic of shivers syndrome. Journal of the American Veterinary Medical Association — PubMed:PMID14567431 — OMIA Phene_Article / Article
- 1955. Lumbar lameness caused by inherited muscle atrophy inhorse. Journal of the Japanese Veterinary Medical Association — OMIA Phene_Article / Article
- 2013. Genome-wide association analysis of Shivers in Belgian horses. Equine Genome Workshop, Plan and Animal Genome XXI, San Diego, CA — OMIA Phene_Article / Article
- 2015. The equine movement disorder "Shivers" is associated with selective cerebellar Purkinje cell axonal degeneration. Vet Pathol — PubMed:PMID25714471 | DOI:10.1177/0300985815571668 — OMIA Phene_Article / Article
- 2018. Abnormal locomotor muscle recruitment activity is present in horses with shivering and Purkinje cell distal axonopathy. Equine Vet J — PubMed:PMID29356055 | DOI:10.1111/evj.12813 — OMIA Phene_Article / Article
- 2022. Shivering and Stringhalt in horses. Vet J — PubMed:PMID35462036 | DOI:10.1016/j.tvjl.2022.105829 — OMIA Phene_Article / Article
- 2023. Cerebellar axonopathy in Shivers horses identified by spatial transcriptomic and proteomic analyses. J Vet Intern Med — PubMed:PMID37288990 | DOI:10.1111/jvim.16784 — OMIA Phene_Article / Article
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1999. Clinical and pathologic findings in two draft horses with progressive muscle atrophy, neuromuscular weakness, and abnormal gait characteristic of shivers syndrome. Journal of the American Veterinary Medical Association — PubMed:PMID14567431 — OMIA Phene_Article / Article
- 1955. Lumbar lameness caused by inherited muscle atrophy inhorse. Journal of the Japanese Veterinary Medical Association — OMIA Phene_Article / Article
- 2013. Genome-wide association analysis of Shivers in Belgian horses. Equine Genome Workshop, Plan and Animal Genome XXI, San Diego, CA — OMIA Phene_Article / Article
- 2015. The equine movement disorder "Shivers" is associated with selective cerebellar Purkinje cell axonal degeneration. Vet Pathol — PubMed:PMID25714471 | DOI:10.1177/0300985815571668 — OMIA Phene_Article / Article
- 2018. Abnormal locomotor muscle recruitment activity is present in horses with shivering and Purkinje cell distal axonopathy. Equine Vet J — PubMed:PMID29356055 | DOI:10.1111/evj.12813 — OMIA Phene_Article / Article
- 2022. Shivering and Stringhalt in horses. Vet J — PubMed:PMID35462036 | DOI:10.1016/j.tvjl.2022.105829 — OMIA Phene_Article / Article
- 2023. Cerebellar axonopathy in Shivers horses identified by spatial transcriptomic and proteomic analyses. J Vet Intern Med — PubMed:PMID37288990 | DOI:10.1111/jvim.16784 — OMIA Phene_Article / Article