Hamster — Coat colour, black tremor (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Mesocricetus auratus / Phodopus spp. (hamster)Disorder:Summary: "The hamster black tremor (bt) mutation induces a black coat color and a defective myelination in the central nervous system (CNS) that manifests as a tremor." (Kuramoto et al., 2002)Defect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 392710362 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Kuramoto et al. (2002) reported "an approximately 10-kb DNA fragment, which had 557-bp direct repeats in both ends and was flanked by the identical 6-bp target duplication sequences, [that] was inserted into exon 24" as a likely causal variant.
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2002. Insertional mutation of the Attractin gene in the black tremor hamster. Mamm Genome — PubMed:PMID11773967 — OMIA Phene_Article / Article
- 1986. [Genetical analysis and characterization of a new mutant, black tremor appearing in the Syrian hamster]. Jikken Dobutsu — PubMed:PMID3732409 | DOI:10.1538/expanim1978.35.2_175 — OMIA Phene_Article / Article
- 2003. Myelin-deficiency in the cochlear nerve of the 'bt' mutant hamster. Hear Res — PubMed:PMID12583878 | DOI:10.1016/s0378-5955(02)00550-6 — OMIA Phene_Article / Article
- 2003. Sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster. Jpn J Vet Res — PubMed:PMID14621228 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:603130 (type: gene) — OMIA Group_OMIM (via OMIA_ID)