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Dalmatian — similar to Alport syndrome in humans (hereditary; OMIA-verified breed predisposition)

companion_breed_health_dalmatian_similar_to_alport_syndrome_in_humans_dog

Other Compilations derived_from_dataset companion-breed-health

--- license: permission_granted topic_id: companion_breed_health_dalmatian_similar_to_alport_syndrome_in_humans_dog category: companion-breed-health title: "Dalmatian — similar to Alport syndrome in humans (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/dalmatian_similar_to_alport_syndrome_in_humans_52.txt date_parsed: 2026-08-02 tokens_estimated: 149 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_dalmatian_similar_to_alport_syndrome_in_humans_dog/01_companion_breed_health_dalmatian_similar_to_alport_syndrome_in_humans_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dalmatian — similar to Alport syndrome in humans (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001114/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Dalmatian — similar to Alport syndrome in humans (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: Dalmatian (Dog)
  • Disorder: similar to Alport syndrome in humans
  • Mode of inheritance: Autosomal dominant
  • Summary: The first report of this disorder in dogs was in Bull Terriers, by Hood et al. (1990). The same disorder in Dalmations was reported by Hood et al. (2002) [FN 13 Jan 2003]. For other types of hereditary nephritis see also: 'OMIA001359-9615 Nephritis, autosomal recessive'; 'OMIA001112-9615 Nephritis, x-linked' ;OMIA000708-9615 Nephritis' and 'OMIA 000413-9615 Glomerulonephritis'.
  • Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1990. Hereditary nephritis in the bull terrier: evidence for inheritance by an autosomal dominant gene.. Vet Rec — PubMed:PMID2356601 — OMIA Phene_Article / Article
  • 1991. Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis.. Journal of Small Animal Practice — OMIA Phene_Article / Article
  • 1995. Bull terrier hereditary nephritis: a model for autosomal dominant Alport syndrome.. Kidney Int — PubMed:PMID7752574 | DOI:10.1038/ki.1995.116 — OMIA Phene_Article / Article
  • 2002. A novel model of autosomal dominant Alport syndrome in Dalmatian dogs. Nephrology Dialysis Transplantation — OMIA Phene_Article / Article
  • 1994. Hereditary nephritis in a miniature bull terrier.. Vet Rec — PubMed:PMID7975107 — OMIA Phene_Article / Article
  • 2000. Ultrastructural appearance of renal and other basement membranes in the Bull terrier model of autosomal dominant hereditary nephritis.. Am J Kidney Dis — PubMed:PMID10922317 | DOI:10.1053/ajkd.2000.8989 — OMIA Phene_Article / Article
  • 2002. Correlation of histopathological features and renal impairment in autosomal dominant Alport syndrome in Bull terriers.. Nephrol Dial Transplant — PubMed:PMID12401844 — OMIA Phene_Article / Article
  • 2002. Animal models of Alport syndrome.. Nephrol Dial Transplant — PubMed:PMID12147777 | DOI:10.1093/ndt/17.8.1359 — OMIA Phene_Article / Article
  • 2009. Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers.. Anim Genet — PubMed:PMID19133935 | DOI:10.1111/j.1365-2052.2008.01829.x — OMIA Phene_Article / Article
  • 2005. Canine COL4A3 and COL4A4: sequencing, mapping and genomic organization.. DNA Seq — PubMed:PMID16147883 | DOI:10.1080/10425170500136822 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:104200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1990. Hereditary nephritis in the bull terrier: evidence for inheritance by an autosomal dominant gene. Vet Rec — PubMed:PMID2356601 — OMIA Phene_Article / Article
  • 1991. Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis. Journal of Small Animal Practice — OMIA Phene_Article / Article
  • 1995. Bull terrier hereditary nephritis: a model for autosomal dominant Alport syndrome. Kidney Int — PubMed:PMID7752574 | DOI:10.1038/ki.1995.116 — OMIA Phene_Article / Article
  • 2002. A novel model of autosomal dominant Alport syndrome in Dalmatian dogs. Nephrology Dialysis Transplantation — OMIA Phene_Article / Article
  • 1994. Hereditary nephritis in a miniature bull terrier. Vet Rec — PubMed:PMID7975107 — OMIA Phene_Article / Article
  • 2000. Ultrastructural appearance of renal and other basement membranes in the Bull terrier model of autosomal dominant hereditary nephritis. Am J Kidney Dis — PubMed:PMID10922317 | DOI:10.1053/ajkd.2000.8989 — OMIA Phene_Article / Article
  • 2002. Correlation of histopathological features and renal impairment in autosomal dominant Alport syndrome in Bull terriers. Nephrol Dial Transplant — PubMed:PMID12401844 — OMIA Phene_Article / Article
  • 2002. Animal models of Alport syndrome. Nephrol Dial Transplant — PubMed:PMID12147777 | DOI:10.1093/ndt/17.8.1359 — OMIA Phene_Article / Article
  • 2009. Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers. Anim Genet — PubMed:PMID19133935 | DOI:10.1111/j.1365-2052.2008.01829.x — OMIA Phene_Article / Article
  • 2005. Canine COL4A3 and COL4A4: sequencing, mapping and genomic organization. DNA Seq — PubMed:PMID16147883 | DOI:10.1080/10425170500136822 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:104200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1990. Hereditary nephritis in the bull terrier: evidence for inheritance by an autosomal dominant gene. Vet Rec — PubMed:PMID2356601 — OMIA Phene_Article / Article
  • 1991. Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis. Journal of Small Animal Practice — OMIA Phene_Article / Article
  • 1995. Bull terrier hereditary nephritis: a model for autosomal dominant Alport syndrome. Kidney Int — PubMed:PMID7752574 | DOI:10.1038/ki.1995.116 — OMIA Phene_Article / Article
  • 2002. A novel model of autosomal dominant Alport syndrome in Dalmatian dogs. Nephrology Dialysis Transplantation — OMIA Phene_Article / Article
  • 1994. Hereditary nephritis in a miniature bull terrier. Vet Rec — PubMed:PMID7975107 — OMIA Phene_Article / Article
  • 2000. Ultrastructural appearance of renal and other basement membranes in the Bull terrier model of autosomal dominant hereditary nephritis. Am J Kidney Dis — PubMed:PMID10922317 | DOI:10.1053/ajkd.2000.8989 — OMIA Phene_Article / Article
  • 2002. Correlation of histopathological features and renal impairment in autosomal dominant Alport syndrome in Bull terriers. Nephrol Dial Transplant — PubMed:PMID12401844 — OMIA Phene_Article / Article
  • 2002. Animal models of Alport syndrome. Nephrol Dial Transplant — PubMed:PMID12147777 | DOI:10.1093/ndt/17.8.1359 — OMIA Phene_Article / Article
  • 2009. Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers. Anim Genet — PubMed:PMID19133935 | DOI:10.1111/j.1365-2052.2008.01829.x — OMIA Phene_Article / Article
  • 2005. Canine COL4A3 and COL4A4: sequencing, mapping and genomic organization. DNA Seq — PubMed:PMID16147883 | DOI:10.1080/10425170500136822 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:104200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1990. Hereditary nephritis in the bull terrier: evidence for inheritance by an autosomal dominant gene. Vet Rec — PubMed:PMID2356601 — OMIA Phene_Article / Article
  • 1991. Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis. Journal of Small Animal Practice — OMIA Phene_Article / Article
  • 1995. Bull terrier hereditary nephritis: a model for autosomal dominant Alport syndrome. Kidney Int — PubMed:PMID7752574 | DOI:10.1038/ki.1995.116 — OMIA Phene_Article / Article
  • 2002. A novel model of autosomal dominant Alport syndrome in Dalmatian dogs. Nephrology Dialysis Transplantation — OMIA Phene_Article / Article
  • 1994. Hereditary nephritis in a miniature bull terrier. Vet Rec — PubMed:PMID7975107 — OMIA Phene_Article / Article
  • 2000. Ultrastructural appearance of renal and other basement membranes in the Bull terrier model of autosomal dominant hereditary nephritis. Am J Kidney Dis — PubMed:PMID10922317 | DOI:10.1053/ajkd.2000.8989 — OMIA Phene_Article / Article
  • 2002. Correlation of histopathological features and renal impairment in autosomal dominant Alport syndrome in Bull terriers. Nephrol Dial Transplant — PubMed:PMID12401844 — OMIA Phene_Article / Article
  • 2002. Animal models of Alport syndrome. Nephrol Dial Transplant — PubMed:PMID12147777 | DOI:10.1093/ndt/17.8.1359 — OMIA Phene_Article / Article
  • 2009. Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers. Anim Genet — PubMed:PMID19133935 | DOI:10.1111/j.1365-2052.2008.01829.x — OMIA Phene_Article / Article
  • 2005. Canine COL4A3 and COL4A4: sequencing, mapping and genomic organization. DNA Seq — PubMed:PMID16147883 | DOI:10.1080/10425170500136822 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:104200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1990. Hereditary nephritis in the bull terrier: evidence for inheritance by an autosomal dominant gene. Vet Rec — PubMed:PMID2356601 — OMIA Phene_Article / Article
  • 1991. Proteinuria as an indicator of early renal disease in bull terriers with hereditary nephritis. Journal of Small Animal Practice — OMIA Phene_Article / Article
  • 1995. Bull terrier hereditary nephritis: a model for autosomal dominant Alport syndrome. Kidney Int — PubMed:PMID7752574 | DOI:10.1038/ki.1995.116 — OMIA Phene_Article / Article
  • 2002. A novel model of autosomal dominant Alport syndrome in Dalmatian dogs. Nephrology Dialysis Transplantation — OMIA Phene_Article / Article
  • 1994. Hereditary nephritis in a miniature bull terrier. Vet Rec — PubMed:PMID7975107 — OMIA Phene_Article / Article
  • 2000. Ultrastructural appearance of renal and other basement membranes in the Bull terrier model of autosomal dominant hereditary nephritis. Am J Kidney Dis — PubMed:PMID10922317 | DOI:10.1053/ajkd.2000.8989 — OMIA Phene_Article / Article
  • 2002. Correlation of histopathological features and renal impairment in autosomal dominant Alport syndrome in Bull terriers. Nephrol Dial Transplant — PubMed:PMID12401844 — OMIA Phene_Article / Article
  • 2002. Animal models of Alport syndrome. Nephrol Dial Transplant — PubMed:PMID12147777 | DOI:10.1093/ndt/17.8.1359 — OMIA Phene_Article / Article
  • 2009. Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers. Anim Genet — PubMed:PMID19133935 | DOI:10.1111/j.1365-2052.2008.01829.x — OMIA Phene_Article / Article
  • 2005. Canine COL4A3 and COL4A4: sequencing, mapping and genomic organization. DNA Seq — PubMed:PMID16147883 | DOI:10.1080/10425170500136822 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:104200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

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