{"topic_id":"fda_gras_001","category":"us-2026","context":"---\ntopic_id: fda_gras_001\ncategory: FDA-GRAS\ntitle: FDA GRAS notices_csv\nlang: en\nsource: fda_gras_notices_20260714.csv\ndate_parsed: 2026-07-18\ntokens_estimated: 6938\n\nextra: {\"entry_count\": 365, \"source_tag\": \"notices_csv\"}\n---\n\n# FDA GRAS notices_csv\n\n**Total entries:** 365\n\n## Source: fda_gras_notices_20260714.csv\n\n**Columns:** GRN No.(sorted A-Z), Substance, Date of closure, FDA's Letter, Date of add'l correspondence, Resubmitted as GRN No.\n\n## Sample entries (first 50):\n- {\"GRN No.(sorted A-Z)\": \"1\", \"Substance\": \"Soy isoflavone extract\", \"Date of closure\": \"Nov 3, 1998\", \"FDA's Letter\": \"At the notifier's request, FDA ceased to evaluate this notice\", \"Date of add'l co\n- {\"GRN No.(sorted A-Z)\": \"2\", \"Substance\": \"Solin oil (low linolenic acid flaxseed oil or low linolenic acid linseed oil)\", \"Date of closure\": \"May 27, 1998\", \"FDA's Letter\": \"FDA has no questions\", \"D\n- {\"GRN No.(sorted A-Z)\": \"3\", \"Substance\": \"Sodium bisulfate\", \"Date of closure\": \"Jun 5, 1998\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitted as GRN No.\": \"\"\n- {\"GRN No.(sorted A-Z)\": \"4\", \"Substance\": \"Transglutaminase fromStreptoverticillium mobaraense\", \"Date of closure\": \"Jun 22, 1998\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondenc\n- {\"GRN No.(sorted A-Z)\": \"5\", \"Substance\": \"Tasteless smoke\", \"Date of closure\": \"Nov 9, 1998\", \"FDA's Letter\": \"At the notifier's request, FDA ceased to evaluate this notice\", \"Date of add'l correspon\n- {\"GRN No.(sorted A-Z)\": \"6\", \"Substance\": \"Dioctyl sodium sulfosuccinate\", \"Date of closure\": \"Dec 28, 1998\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitted a\n- {\"GRN No.(sorted A-Z)\": \"7\", \"Substance\": \"ARASCO (arachidonic acid-rich single-cell oil) and DHASCO (docosahexaenoic acid-rich single-cell oil) as sources of the fatty acids ARA (arachidonic acid) an\n- {\"GRN No.(sorted A-Z)\": \"8\", \"Substance\": \"Pectin esterase derived fromAspergillus oryzaecarrying a gene encoding pectin esterase fromAspergillus aculeatus\", \"Date of closure\": \"Mar 2, 1999\", \"FDA's L\n- {\"GRN No.(sorted A-Z)\": \"9\", \"Substance\": \"Polyglycerol polyricinoleic acid\", \"Date of closure\": \"Mar 2, 1999\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitted\n- {\"GRN No.(sorted A-Z)\": \"10\", \"Substance\": \"Exopeptidase derived fromAspergillus oryzaecarrying a gene encoding a leucine aminopeptidase fromAspergillus sojae\", \"Date of closure\": \"Jan 29, 1999\", \"FDA\n- {\"GRN No.(sorted A-Z)\": \"11\", \"Substance\": \"Calcium casein peptone-calcium phosphate\", \"Date of closure\": \"Jan 29, 1999\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"R\n- {\"GRN No.(sorted A-Z)\": \"12\", \"Substance\": \"Mesquite wood alcoholic extract\", \"Date of closure\": \"Mar 11, 1999\", \"FDA's Letter\": \"At the notifier's request, FDA ceased to evaluate this notice\", \"Date \n- {\"GRN No.(sorted A-Z)\": \"13\", \"Substance\": \"Botanicals: Chrysanthemum; Licorice; Jellywort ANDHoneysuckle; Lophatherum; Mulberry leaf; Frangipani; Selfheal; Sophora flower bud\", \"Date of closure\": \"Ju\n- {\"GRN No.(sorted A-Z)\": \"14\", \"Substance\": \"Hydrogen peroxide\", \"Date of closure\": \"May 26, 1999\", \"FDA's Letter\": \"Notice does not provide a basis for a GRAS determination\", \"Date of add'l correspond\n- {\"GRN No.(sorted A-Z)\": \"15\", \"Substance\": \"Tasteless smoke(Resubmission of GRN5)\", \"Date of closure\": \"Mar 10, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resu\n- {\"GRN No.(sorted A-Z)\": \"16\", \"Substance\": \"Menhaden oil\", \"Date of closure\": \"Jun 8, 1999\", \"FDA's Letter\": \"At the notifier's request, FDA ceased to evaluate this notice\", \"Date of add'l corresponde\n- {\"GRN No.(sorted A-Z)\": \"17\", \"Substance\": \"Arabinogalactan\", \"Date of closure\": \"Apr 11, 2000\", \"FDA's Letter\": \"At the notifier's request, FDA ceased to evaluate this notice\", \"Date of add'l corresp\n- {\"GRN No.(sorted A-Z)\": \"18\", \"Substance\": \"Mesquite (Prosopisspp.) wood alcoholic extract(Resubmission of GRN12)\", \"Date of closure\": \"May 12, 1999\", \"FDA's Letter\": \"FDA has no questions\", \"Date of \n- {\"GRN No.(sorted A-Z)\": \"19\", \"Substance\": \"Ferrous bisglycinate chelate\", \"Date of closure\": \"Sep 30, 1999\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitted a\n- {\"GRN No.(sorted A-Z)\": \"20\", \"Substance\": \"Pullulanase derived fromBacillus subtiliscarrying a gene encoding pullulanase fromBacillus naganoensis\", \"Date of closure\": \"Sep 30, 1999\", \"FDA's Letter\": \n- {\"GRN No.(sorted A-Z)\": \"21\", \"Substance\": \"Pork collagen\", \"Date of closure\": \"Jul 29, 1999\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitted as GRN No.\": \"\"}\n- {\"GRN No.(sorted A-Z)\": \"22\", \"Substance\": \"alpha-Amylase derived fromBacillus licheniformiscarrying a gene encoding a modified alpha-amylase derived fromBacillus lichenformisandBacillus amyloliquefac\n- {\"GRN No.(sorted A-Z)\": \"23\", \"Substance\": \"Protein preparation from animal blood\", \"Date of closure\": \"Aug 2, 1999\", \"FDA's Letter\": \"At the notifier's request, FDA ceased to evaluate this notice\", \"\n- {\"GRN No.(sorted A-Z)\": \"24\", \"Substance\": \"alpha-Amylase derived fromBacillus licheniformiscarrying a gene encoding alpha-amylase fromBacillus stearothermophilus\", \"Date of closure\": \"May 15, 2000\", \n- {\"GRN No.(sorted A-Z)\": \"25\", \"Substance\": \"Extract ofGarcinia kolaseed (\\\"bitter cola\\\")\", \"Date of closure\": \"Oct 12, 1999\", \"FDA's Letter\": \"Notice does not provide a basis for a GRAS determination\n- {\"GRN No.(sorted A-Z)\": \"26\", \"Substance\": \"Isolated wheat protein\", \"Date of closure\": \"Dec 16, 1999\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitted as GRN \n- {\"GRN No.(sorted A-Z)\": \"27\", \"Substance\": \"Dextranase fromChaetomium gracile\", \"Date of closure\": \"Dec 16, 1999\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmit\n- {\"GRN No.(sorted A-Z)\": \"28\", \"Substance\": \"Seaweed-derived calcium\", \"Date of closure\": \"Apr 21, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"Mar 19, 2014Mar 27, 20\n- {\"GRN No.(sorted A-Z)\": \"29\", \"Substance\": \"Transglutaminase fromStreptoverticillium mobaraense\", \"Date of closure\": \"Dec 29, 1999\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l corresponden\n- {\"GRN No.(sorted A-Z)\": \"30\", \"Substance\": \"Crospovidone-cranberry juice extract\", \"Date of closure\": \"Dec 20, 1999\", \"FDA's Letter\": \"Notice does not provide a basis for a GRAS determination\", \"Date \n- {\"GRN No.(sorted A-Z)\": \"31\", \"Substance\": \"Cetylpyridinium chloride\", \"Date of closure\": \"Jan 10, 2000\", \"FDA's Letter\": \"At the notifier's request, FDA ceased to evaluate this notice\", \"Date of add'\n- {\"GRN No.(sorted A-Z)\": \"32\", \"Substance\": \"Pectin lyase derived fromTrichoderma reeseicarrying a gene encoding pectin lyase fromAspergillus niger\", \"Date of closure\": \"Apr 20, 2000\", \"FDA's Letter\": \n- {\"GRN No.(sorted A-Z)\": \"33\", \"Substance\": \"Low erucic acid oil derived fromBrassica juncea\", \"Date of closure\": \"Jan 27, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\":\n- {\"GRN No.(sorted A-Z)\": \"34\", \"Substance\": \"Aspartic proteinase derived fromAspergillus oryzaecarrying a gene encoding aspartic proteinase fromRhizomucor miehei\", \"Date of closure\": \"Apr 19, 2000\", \"F\n- {\"GRN No.(sorted A-Z)\": \"35\", \"Substance\": \"Hempseed oil\", \"Date of closure\": \"Aug 24, 2000\", \"FDA's Letter\": \"Notice does not provide a basis for a GRAS determination\", \"Date of add'l correspondence\"\n- {\"GRN No.(sorted A-Z)\": \"36\", \"Substance\": \"Chromium picolinate;Ginkgo bilobaleaf extract; and Ginseng extract\", \"Date of closure\": \"Apr 10, 2000\", \"FDA's Letter\": \"At the notifier's request, FDA ceas\n- {\"GRN No.(sorted A-Z)\": \"37\", \"Substance\": \"Whey protein isolate and dairy product solids\", \"Date of closure\": \"Apr 21, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\n- {\"GRN No.(sorted A-Z)\": \"38\", \"Substance\": \"Cetylpyridinium chloride(Resubmission of GRN31)\", \"Date of closure\": \"Feb 29, 2000\", \"FDA's Letter\": \"Notice does not provide a basis for a GRAS determinati\n- {\"GRN No.(sorted A-Z)\": \"39\", \"Substance\": \"Tall oil phytosterols\", \"Date of closure\": \"Apr 24, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"Nov 2, 2000\", \"Resubmitt\n- {\"GRN No.(sorted A-Z)\": \"40\", \"Substance\": \"Mineral oil\", \"Date of closure\": \"Dec 11, 2000\", \"FDA's Letter\": \"Notice does not provide a basis for a GRAS determination\", \"Date of add'l correspondence\":\n- {\"GRN No.(sorted A-Z)\": \"41\", \"Substance\": \"DHASCO (docosahexaenoic acid-rich single-cell oil) and ARASCO (arachidonic acid-rich single-cell oil)(Resubmission of GRN7)\", \"Date of closure\": \"May 17, 20\n- {\"GRN No.(sorted A-Z)\": \"42\", \"Substance\": \"Milk-derived lactoferrin\", \"Date of closure\": \"Mar 26, 2001\", \"FDA's Letter\": \"Notice does not provide a basis for a GRAS determination\", \"Date of add'l cor\n- {\"GRN No.(sorted A-Z)\": \"43\", \"Substance\": \"Lipase derived fromAspergillus oryzaecarrying a gene encoding lipase fromThermomyces lanuginosus\", \"Date of closure\": \"Sep 22, 2000\", \"FDA's Letter\": \"FDA h\n- {\"GRN No.(sorted A-Z)\": \"44\", \"Substance\": \"Fructooligosaccharide\", \"Date of closure\": \"Nov 22, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"Jun 1, 2007\", \"Resubmitt\n- {\"GRN No.(sorted A-Z)\": \"45\", \"Substance\": \"Trehalose\", \"Date of closure\": \"Oct 5, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitted as GRN No.\": \"\"}\n- {\"GRN No.(sorted A-Z)\": \"46\", \"Substance\": \"Gamma cyclodextrin\", \"Date of closure\": \"Sep 22, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitted as GRN No.\"\n- {\"GRN No.(sorted A-Z)\": \"47\", \"Substance\": \"Arabinogalactan fromLarix occidentalis(Resubmission of GRN17)\", \"Date of closure\": \"Jun 6, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l cor\n- {\"GRN No.(sorted A-Z)\": \"48\", \"Substance\": \"Vegetable oil phytosterol esters\", \"Date of closure\": \"Nov 27, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitt\n- {\"GRN No.(sorted A-Z)\": \"49\", \"Substance\": \"Bifidobacterium lactisstrain Bb12 andStreptococcus thermophilusstrain Th4\", \"Date of closure\": \"Mar 19, 2002\", \"FDA's Letter\": \"FDA has no questions\", \"Date\n- {\"GRN No.(sorted A-Z)\": \"50\", \"Substance\": \"Bohenin\", \"Date of closure\": \"Aug 31, 2000\", \"FDA's Letter\": \"FDA has no questions\", \"Date of add'l correspondence\": \"\", \"Resubmitted as GRN No.\": \"\"}\n\n... and 315 more\n\n","sources":[],"tokens_estimated":6938,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}