{"topic_id":"evidence_feline_stomatitis_gingivostomatitis","category":"evidence","context":"---\ntopic_id: evidence_feline_stomatitis_gingivostomatitis\ncategory: evidence\ntitle: \"Evidence cluster — feline chronic gingivostomatitis (FCGS): management & treatment (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-07-24\"\nsource_file: pdf-raw/evidence/pubmed_evidence_feline_stomatitis_gingivostomatitis_2026-07-24.txt\ndate_parsed: 2026-07-24\ntokens_estimated: 420\nverified: true\nverification:\n  method: substring_match\n  claims: 6\n  passed: 6\n  date: 2026-07-24\n---\n\n# Evidence: feline chronic gingivostomatitis (FCGS): management & treatment (peer-reviewed, Europe PMC)\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-07-24. Query: `(\"feline chronic gingivostomatitis\" OR \"feline gingivostomatitis\" OR FCGS) AND (treatment OR management OR therapy)`. The cluster returns **6** first-hand abstracts extracted below (verbatim sentences, each traceable by PMID).\n\n## Verified claims (verbatim, substring of saved source)\n- **PMID 42249348** — Background Feline chronic gingivostomatitis (FCGS) is a debilitating inflammatory condition characterized by severe caudal oral mucosal inflammation and frequently necessitates extensive dental extractions.\n- **PMID 42375508** — Introduction Feline chronic gingivostomatitis (FCGS) is a painful chronic disease with limited treatment options, especially in severe cases.\n- **PMID 42091972** — Feline chronic gingivostomatitis (FCGS) is a debilitating oral disease characterized by immune dysregulation and chronic inflammation.\n- **PMID 42326482** — Feline chronic gingivostomatitis (FCGS) is characterized by persistent oral inflammation, leading to severe pain, hyporexia, weight loss, and reduced well-being.\n- **PMID 41757710** — ObjectivesThe study primarily evaluated the long-term safety of intravenous, allogeneic uterine-derived mesenchymal stromal cells (UMSCs) for client-owned cats affected with refractory feline chronic gingivostomatitis (FCGS).\n- **PMID 42076735** — Background Feline chronic gingivostomatitis (FCGS) is refractory stomatitis in cats.\n\n## Studies (PMID / year / journal / title)\n- **PMID 42249348 (2026, BMC veterinary research)** — Unilateral partial-mouth extraction achieves complete clinical remission in cats with unilateral caudal feline chronic gingivostomatitis: a case series.\n- **PMID 42375508 (2026, Frontiers in veterinary science)** — Evaluating the safety and efficacy of equine peripheral blood-derived mesenchymal stem cells in feline chronic gingivostomatitis.\n- **PMID 42091972 (2026, Scientific reports)** — Transcriptomic evidence of CD8⁺ T-cell exhaustion-like phenotype and mitochondrial impairment underlying immune dysregulation in feline chronic gingivostomatitis.\n- **PMID 42326482 (2026, Brazilian journal of veterinary medicine)** — Comparison of simple and rapid collection methods for measuring salivary IL-6 and PGE<sub>2</sub> in cats with chronic gingivostomatitis: a pilot study.\n- **PMID 41757710 (2026, Journal of feline medicine and surgery)** — Long-term field safety study evaluating allogeneic, uterine-derived mesenchymal stem cells for refractory feline chronic gingivostomatitis.\n- **PMID 42076735 (2026, Veterinary sciences)** — Combination Therapeutic Effect of Antibacterial and Antiviral Agents on Feline Chronic Gingivostomatitis Nonbounded to Prior Tooth Extraction Confirmed by Physical Signs and Clinical Biomarkers.\n\nSource text: `pdf-raw/evidence/pubmed_evidence_feline_stomatitis_gingivostomatitis_2026-07-24.txt` (Europe PMC first-hand abstracts, pulled 2026-07-24).\n","sources":[],"tokens_estimated":562,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}